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Proteins/UNIPROT:Q14032
Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine. More than 95% of the BAs are N-acyl amidates with glycine and taurine. Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism. This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption. May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs..
Function from UniProtKB (Q14032), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · substrate of
2 compounds
2 compounds.
0 reported routes2 assembled routes
3 rows
165 statements
165 statements · 7 reference databases · Subject: BAAT · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
136 reactions
CHEBI:15519+glycineCHEBI:1146900+glycocholate
Catalysed by BAAT
Reaction pageLeft to rightBalancedEC 2.3.1.65peroxisome
Human-GEM MAR00083CC BY 4.0Reference data
glycine+MAM03548xCHEBI:1146900+glycochenodeoxycholic acid
Catalysed by BAAT
Reaction pageLeft to rightBalancedEC 2.3.1.65peroxisome
6 names
Resolves to: BAAT
CHEBI:28701+glycineCHEBI:1146900+glycochenodeoxycholic acid
Catalysed by BAAT
Reaction pageLeft to rightBalancedEC 2.3.1.65peroxisome
Human-GEM MAR00085CC BY 4.0Reference data
water+dodecanoyl-CoACHEBI:1146900+proton+dodecanoate
Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13
Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol
Human-GEM MAR00189CC BY 4.0Reference data
water+MAM03050cCHEBI:1146900+proton+MAM03051c
Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13
Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol
Human-GEM MAR00193CC BY 4.0Reference data
water+tetradecanoyl-CoACHEBI:1146900+proton+tetradecanoate
Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4
Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol
Human-GEM MAR00197CC BY 4.0Reference data
MAM00129c+waterMAM00128c+CHEBI:1146900+proton
Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4
Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol
Human-GEM MAR00201CC BY 4.0Reference data
(7Z)-tetradecenoyl-CoA+waterMAM00117c+CHEBI:1146900+proton
Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4
Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol
Human-GEM MAR00206CC BY 4.0Reference data
(5Z)-tetradecenoyl-CoA+waterCHEBI:1146900+proton+MAM02745c
Catalysed by ACOT1 or ACOT7 or BAAT or THEM4
Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol
Human-GEM MAR00210CC BY 4.0Reference data
water+MAM02689cCHEBI:1146900+proton+MAM02690c
Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4
Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol
Human-GEM MAR00214CC BY 4.0Reference data
water+palmitoyl-CoACHEBI:1146900+proton+hexadecanoic acid
Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4
Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol
Human-GEM MAR00223CC BY 4.0Reference data
water+(9Z)-hexadecenoyl-CoACHEBI:1146900+proton+(9Z)-hexadecenoate
Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4
Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol
Human-GEM MAR00230CC BY 4.0Reference data