Loading the page.
Proteins/UNIPROT:P35790
Plays a key role in phospholipid biosynthesis by catalyzing the phosphorylation of free choline to phosphocholine, the first step in phosphatidylcholine biosynthesis. Also phosphorylates ethanolamine, thereby contributing to phosphatidylethanolamine biosynthesis. Has higher activity with choline. May contribute to tumor cell growth..
[Isoform 1]: This isoform plays a key role in lipolysis of lipid droplets following glucose deprivation. In response to glucose deprivation, phosphorylated by AMPK, promoting localization to lipid droplets. Phosphorylation is followed by acetylation by KAT5, leading to dissociation of the homodimer into a monomer. Monomeric CHKA isoform 1 is converted into a tyrosine-protein kinase, which phosphorylates lipid droplet structural proteins PLIN2 and PLIN3, leading to lipolysis of lipid droplets..
Function from UniProtKB (P35790), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
1 row
132 statements
132 statements · 6 reference databases · Subject: CHKA · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
5 reactions
ATP+cholineADP+proton+CHEBI:18132
Reaction pageLeft to rightBalancedEC 2.7.1.32cytosol
Human-GEM MAR00636CC BY 4.0Reference data
ATP+ethanolamineADP+O-phosphoethanolamine+proton
Catalysed by CHKB
6 names
Resolves to: CHKA
Reaction pageLeft to rightBalancedEC 2.7.1.82cytosol
Human-GEM MAR00648CC BY 4.0Reference data
L-tyrosyl-[protein]+ATP(4-)O-phospho-L-tyrosyl-[protein]+ADP(3-)+hydron
Catalysed by MAP2K7 or MUSK or RIPK2 or DYRK3 or JAK2 or STK16 or ABL1 or EGFR or ERBB2 or NTRK1 or INSR or LCK and 104 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:10596CC BY 4.0Reference data
choline+ATP(4-)phosphocholine+ADP(3-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:12837CC BY 4.0Reference data
ethanolamine+ATP(4-)phosphoethanolamine+ADP(3-)+hydron
Catalysed by CHKA or ETNK1 or ETNK2 or CHKB
Reaction pageLeft to rightBalanced
Rhea RHEA:13069CC BY 4.0Reference data