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Proteins/UNIPROT:Q8WU03
Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0-CoA, to form a variety of N-acylglycines. Shows a preference for monounsaturated fatty acid oleoyl-CoA (C18:1-CoA) as an acyl donor. Does not exhibit any activity toward C22:6-CoA and chenodeoxycholoyl-CoA, nor toward serine or alanine..
Function from UniProtKB (Q8WU03), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
52 statements
52 statements · 4 reference databases · Subject: GLYATL2 · Sources: Human-GEM, Reactome, Rhea, WikiPathways
15 reactions
CHEBI:1146900+proton+MAM02558marachidonoyl-CoA+glycine
Catalysed by GLYAT or GLYATL2 or GLYATL1
Reaction pageReversibleBalancedEC 2.3.1.13mitochondrial matrix
Human-GEM MAR03743CC BY 4.0Reference data
CHEBI:1146900+proton+MAM02181mglycine+isobutyryl-CoA
Catalysed by
1 name
Resolves to: GLYATL2
Reaction pageReversibleBalancedEC 2.3.1.13mitochondrial matrix
Human-GEM MAR03750CC BY 4.0Reference data
CHEBI:1146900+proton+MAM02190mglycine+isovaleryl-CoA
Catalysed by GLYAT or GLYATL2 or GLYATL1
Reaction pageReversibleBalancedEC 2.3.1.13mitochondrial matrix
Human-GEM MAR03771CC BY 4.0Reference data
CHEBI:15477+glycineCHEBI:240943+CHEBI:1146900+proton
Catalysed by GLYAT or GLYATL2 or GLYATL1
Reaction pageReversibleBalancedEC 2.3.1.13mitochondrial matrix
Human-GEM MAR03782CC BY 4.0Reference data
an acyl-CoA+glycinean N-acylglycine+coenzyme A(4-)+hydron
Catalysed by GLYATL3 or GLYAT or GLYATL2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:19869CC BY 4.0Reference data
(9Z)-octadecenoyl-CoA+glycineN-(9Z-octadecenoyl)glycine+coenzyme A(4-)+hydron
Catalysed by GLYATL3 or GLYATL2
Reaction pageLeft to rightBalanced
Rhea RHEA:51272CC BY 4.0Reference data
(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA+glycineN-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine+coenzyme A(4-)+hydron
Catalysed by GLYATL2
Reaction pageLeft to rightBalanced
Rhea RHEA:51364CC BY 4.0Reference data
octadecanoyl-CoA+glycineN-octadecanoylglycine+coenzyme A(4-)+hydron
Catalysed by GLYATL2
Reaction pageLeft to rightBalanced
Rhea RHEA:51368CC BY 4.0Reference data
(9Z)-hexadecenoyl-CoA+glycineN-(9Z-hexadecenoyl)-glycine+coenzyme A(4-)+hydron
Catalysed by GLYATL2
Reaction pageLeft to rightBalanced
Rhea RHEA:51372CC BY 4.0Reference data
octanoyl-CoA+glycineN-octanoylglycine+coenzyme A(4-)+hydron
Catalysed by GLYATL2
Reaction pageDirection not assertedBalanced
Rhea RHEA:64240CC BY 4.0Reference data
a fatty acyl-CoA+glycinean N-(fatty acyl)-glycine+coenzyme A(4-)+hydron
Catalysed by GLYATL2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:64244CC BY 4.0Reference data
decanoyl-CoA+glycineN-decanoylglycine+coenzyme A(4-)+hydron
Catalysed by GLYATL2
Reaction pageDirection not assertedBalanced
Rhea RHEA:64248CC BY 4.0Reference data