Compound
homogentisate
A dihydroxy monocarboxylic acid anion that is the conjugate base of (2,6-dihydroxyphenyl)acetic (homogentisic) acid, arising from deprotonation of the carboxy group.
Definition from ChEBI (CHEBI:16169), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C8H7O4
- Mass
- 167.14 g/mol
- Charge
- -1
- InChIKey
- IGMNYECMUMZDDF-UHFFFAOYSA-M
- SMILES
- O=C([O-])Cc1cc(O)ccc1O
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
1 entity
1 entities reached.
0 reported hops1 assembled from the scaffold
What the reference databases state
Chemical structure
- homogentisate has the functional parent acetateCompoundChEBI CHEBI:16169Inferred only
Statements
6 statements
6 statements · 2 reference databases · Subject: homogentisate · Sources: Human-GEM, Rhea
- 3-(4-hydroxyphenyl)pyruvate is converted to homogentisateCompoundHuman-GEM MAR06772Inferred only
- 3-(4-hydroxyphenyl)pyruvate is converted to homogentisateCompoundRhea RHEA:16189Inferred only
- homogentisate is converted to 4-maleylacetoacetateCompoundRhea RHEA:15449Inferred only
- homogentisate is converted to 4-maleylacetoacetic acidCompoundHuman-GEM MAR06774Inferred only
- homogentisate is a substrate of HGDProteinRhea RHEA:15449Inferred only
- homogentisate is a substrate of HGDProteinHuman-GEM MAR06774Inferred only
Reactions
14 reactions
homogentisate+NADPH(4-)+dioxygencarbon dioxide+MAM01952c+water+NADP(3-)
Reaction pageLeft to rightUnbalancedEC 4.1.1.-cytosol
Human-GEM MAR04702CC BY 4.0Reference data
3-(4-hydroxyphenyl)pyruvate+dioxygencarbon dioxide+homogentisate
Catalysed by HPD
Reaction pageLeft to rightBalancedEC 1.13.11.27cytosol
Human-GEM MAR06772CC BY 4.0Reference data
homogentisate+dioxygen4-maleylacetoacetic acid+proton
Catalysed by HGD
Reaction pageLeft to rightBalancedEC 1.13.11.5cytosol
Human-GEM MAR06774CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR10247CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR10370CC BY 4.0Reference data
CHEBI:48999+NADPH(4-)+dioxygen+hydronhomogentisate+NADP(3-)+water
Reaction pageDirection not assertedBalanced
Rhea RHEA:15157CC BY 4.0Reference data
CHEBI:48999+NADH(2-)+dioxygen+hydronhomogentisate+NAD(1-)+water
Reaction pageDirection not assertedBalanced
Rhea RHEA:15161CC BY 4.0Reference data
homogentisate+dioxygen4-maleylacetoacetate+hydron
Catalysed by HGD
Reaction pageLeft to rightBalanced
Rhea RHEA:15449CC BY 4.0Reference data
3-(4-hydroxyphenyl)pyruvate+dioxygenhomogentisate+carbon dioxide
Catalysed by HPD
Reaction pageLeft to rightBalanced
Rhea RHEA:16189CC BY 4.0Reference data
CHEBI:58149+NADPH(4-)+dioxygen+hydronhomogentisate+NADP(3-)+water
Reaction pageDirection not assertedBalanced
Rhea RHEA:22204CC BY 4.0Reference data
CHEBI:58149+NADH(2-)+dioxygen+hydronhomogentisate+NAD(1-)+water
Reaction pageDirection not assertedBalanced
Rhea RHEA:22208CC BY 4.0Reference data
CHEBI:75434+homogentisate+hydronCHEBI:75920+carbon dioxide+diphosphate(3-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:37975CC BY 4.0Reference data
Other names
1 name
Resolves to: homogentisate
- Systematic name
- (2,5-dihydroxyphenyl)acetate