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Proteins/UNIPROT:P43003
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity)..
Function from UniProtKB (P43003), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
1 row
139 statements
139 statements · 7 reference databases · Subject: SLC1A3 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
8 reactions
L-glutamate(1-)+proton+potassium atom+3sodium(1+)L-glutamate(1-)+proton+potassium atom+3sodium(1+)
Transported by SLC1A3 or SLC1A6 or SLC1A1 or SLC1A2 or SLC1A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04932CC BY 4.0Reference data
6 names
Resolves to: SLC1A3
L-aspartate+sodium(1+)L-aspartate+sodium(1+)
Transported by SLC1A3 or SLC1A6 or SLC1A1 or SLC1A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05328CC BY 4.0Reference data
L-glutamate(1-)+sodium(1+)L-glutamate(1-)+sodium(1+)
Transported by SLC1A3 or SLC1A6 or SLC1A1 or SLC1A2 or SLC1A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05330CC BY 4.0Reference data
L-aspartate+proton+potassium atom+3sodium(1+)L-aspartate+proton+potassium atom+3sodium(1+)
Transported by SLC1A3 or SLC1A6 or SLC1A1 or SLC1A2 or SLC1A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05447CC BY 4.0Reference data
D-aspartic acid+proton+potassium atom+3sodium(1+)D-aspartic acid+proton+potassium atom+3sodium(1+)
Transported by SLC1A3 or SLC1A6 or SLC1A1 or SLC1A2 or SLC1A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR07639CC BY 4.0Reference data
K(+)+L-glutamate(1-)+3sodium(1+)+hydronK(+)+L-glutamate(1-)+3sodium(1+)+hydron
Transported by SLC1A7 or SLC1A3 or SLC1A2 or SLC1A1 or SLC1A6
Reaction pageDirection not assertedBalanced
Rhea RHEA:70699CC BY 4.0Reference data
K(+)+L-aspartate+3sodium(1+)+hydronK(+)+L-aspartate+3sodium(1+)+hydron
Transported by SLC1A7 or SLC1A3 or SLC1A2 or SLC1A1 or SLC1A6
Reaction pageDirection not assertedBalanced
Rhea RHEA:70851CC BY 4.0Reference data
D-aspartate+K(+)+3sodium(1+)+hydronD-aspartate+K(+)+3sodium(1+)+hydron
Transported by SLC1A7 or SLC1A3 or SLC1A2 or SLC1A1 or SLC1A6
Reaction pageDirection not assertedBalanced
Rhea RHEA:71379CC BY 4.0Reference data