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4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

6 compounds within 3 steps: 1 in 1, 1 in 2, 4 in 3

Does it reach a compound?

One step

xanthurenateReach from here →
1. 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate to xanthurenate conversion
No catalyst recordedcytosol

Two steps

CHEBI:17380Reach from here →
1. 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate to xanthurenate conversion
2. Kynurenine-Oxoglutarate Transaminase
Catalysed by AADATcytosol, mitochondrial matrixOne of 2 routes

Three steps

3-hydroxyanthranilic acidReach from here →
Catalysed by AADAT, KYNUcytosol, mitochondrial matrix
L-tryptophanReach from here →
Catalysed by AADAT, SLC7A5

cytosol, mitochondrial matrix, extracellular space

One of 2 routes

L-kynurenineReach from here →

4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate to xanthurenate conversion
Kynurenine-Oxoglutarate Transaminase
L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)

Catalysed by AADAT, KMOcytosol, mitochondrial matrix

L-alanineReach from here →

4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate to xanthurenate conversion
Kynurenine-Oxoglutarate Transaminase
3-Hydroxy-L-kynurenine hydrolase

Catalysed by AADAT, KYNUcytosol, mitochondrial matrix