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Proteins/UNIPROT:P17735
Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine..
Function from UniProtKB (P17735), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
1 row
25 statements
25 statements · 7 reference databases · Subject: TAT · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
6 reactions
2-oxoglutarate(2-)+L-phenylalanineL-glutamate(1-)+3-phenylpyruvate
Reaction pageReversibleBalancedEC 2.6.1.58mitochondrial matrix
Human-GEM MAR01616CC BY 4.0Reference data
4-methylthio-2-oxobutanoic acid+L-glutamate(1-)2-oxoglutarate(2-)+L-methionine
Catalysed by TAT
Reaction pageLeft to right
1 name
Resolves to: TAT
Human-GEM MAR05391CC BY 4.0Reference data
2-oxoglutarate(2-)+L-phenylalanineL-glutamate(1-)+3-phenylpyruvate
Catalysed by GOT1 or GOT2 or TAT
Reaction pageReversibleBalancedEC 2.6.1.1, 2.6.1.5, 2.6.1.57cytosol
Human-GEM MAR06725CC BY 4.0Reference data
2-oxoglutarate(2-)+CHEBI:178953-(4-hydroxyphenyl)pyruvate+L-glutamate(1-)
Catalysed by GOT1 or GOT2 or TAT
Reaction pageLeft to rightBalancedEC 2.6.1.1, 2.6.1.5, 2.6.1.57cytosol
Human-GEM MAR06768CC BY 4.0Reference data
2-oxoglutarate(2-)+CHEBI:178953-(4-hydroxyphenyl)pyruvate+L-glutamate(1-)
Reaction pageLeft to rightBalancedEC 2.6.1.5, 2.6.1.57, 2.6.1.1mitochondrial matrix
Human-GEM MAR06780CC BY 4.0Reference data
L-tyrosine+2-oxoglutarate(2-)3-(4-hydroxyphenyl)pyruvate+L-glutamate(1-)
Catalysed by TAT
Reaction pageDirection not assertedBalanced
Rhea RHEA:15093CC BY 4.0Reference data