Compound
isobutyryl-CoA
A short-chain, methyl-branched fatty acyl-CoA that is the S-isobutyryl derivative of coenzyme A.
Definition from ChEBI (CHEBI:15479), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
6 entities
6 entities reached.
0 reported hops6 assembled from the scaffold
- GLYATProteinUNIPROT:Q6IB77substrate ofInferred only15 paths15 endpoints
- ACADSProteinUNIPROT:P16219substrate ofInferred only11 paths11 endpoints
- GLYATL2ProteinUNIPROT:Q8WU03substrate ofInferred only11 paths11 endpoints
- ACADSBProteinUNIPROT:P45954substrate ofInferred only10 paths10 endpoints
- ACAD8ProteinUNIPROT:Q9UKU7substrate ofInferred only6 paths6 endpoints
- DBTProteinUNIPROT:P11182substrate ofInferred only1 path1 endpoint
What the reference databases state
Statements
7 statements
7 statements · 1 reference database · Subject: isobutyryl-CoA · Sources: Human-GEM
- CHEBI:1146900 is converted to isobutyryl-CoACompoundHuman-GEM MAR03534Inferred only
- isobutyryl-CoA is a substrate of ACAD8ProteinHuman-GEM MAR03752Inferred only
- isobutyryl-CoA is a substrate of ACADSProteinHuman-GEM MAR03752Inferred only
- isobutyryl-CoA is a substrate of ACADSBProteinHuman-GEM MAR03752Inferred only
- isobutyryl-CoA is a substrate of DBTProteinHuman-GEM MAR06417Inferred only
- isobutyryl-CoA is a substrate of GLYATProteinHuman-GEM MAR03750Inferred only
- isobutyryl-CoA is a substrate of GLYATL2ProteinHuman-GEM MAR03750Inferred only
Reactions
4 reactions
MAM00845m+CHEBI:1146900CHEBI:15351+isobutyryl-CoA
Catalysed by HADHA & ACAA2 & HADHB
Reaction pageLeft to rightBalancedEC 2.3.1.16, 1.1.1.211GO:0005759
Human-GEM MAR03534CC BY 4.0Reference data
CHEBI:1146900+proton+MAM02181mglycine+isobutyryl-CoA
Reaction pageReversibleBalancedEC 2.3.1.13GO:0005759
Human-GEM MAR03750CC BY 4.0Reference data
FADH2+MAM02468mFAD+isobutyryl-CoA
Catalysed by ACAD8 or ACADS or ACADSB
Reaction pageReversibleBalancedEC 1.3.8.5, 1.3.8.1GO:0005759
Human-GEM MAR03752CC BY 4.0Reference data
CHEBI:1146900+MAM02857mMAM01701m+isobutyryl-CoA
Catalysed by DBT
Reaction pageReversibleBalancedEC 2.3.1.168GO:0005759
Human-GEM MAR06417CC BY 4.0Reference data
Other names
4 names
Resolves to: isobutyryl-CoA
- Also called
- 2-Methylpropanoyl-CoA2-Methylpropionyl-CoAisobutanoyl-CoA
- Systematic name
- 3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-{[3-({2-[(2-methylpropanoyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino}-4-oxobutyl] dihydrogen diphosphate}