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Proteins/UNIPROT:O95237
Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (By similarity)..
Function from UniProtKB (O95237), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
5 rows
33 statements
33 statements · 5 reference databases · Subject: LRAT · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
10 reactions
1,2-diacyl-sn-glycero-3-phosphocholine(1+)+all-trans-retinol1-O-acyl-sn-glycero-3-phosphocholine(1+)+an all-trans-retinyl ester
Catalysed by LRAT
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.135cytosol
Human-GEM MAR01501CC BY 4.0Reference data
1,2-diacyl-sn-glycero-3-phosphocholine(1+)+all-trans-retinolMAM00535c+an all-trans-retinyl ester
1 name
Resolves to: LRAT
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.135, 2.3.1.75cytosol
Human-GEM MAR06635CC BY 4.0Reference data
11-cis-retinol+1,2-diacyl-sn-glycero-3-phosphocholine(1+)MAM00535c+an all-trans-retinyl ester
Catalysed by DGAT2 or RBP2 or RBP1 or LRAT or AWAT2 or DGAT1 or AWAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.135, 2.3.1.75cytosol
Human-GEM MAR06639CC BY 4.0Reference data
11-cis-retinol+palmitoyl-CoA11-cis-retinyl hexadecanoate+CHEBI:1146900
Catalysed by DGAT2 or LRAT or AWAT2 or DGAT1 or AWAT1
Reaction pageReversibleBalancedEC 2.3.1.75, 2.3.1.76, 2.3.1.135cytosol
Human-GEM MAR06671CC BY 4.0Reference data
all-trans-retinol--[retinol-binding protein]+a 1,2-diacyl-sn-glycero-3-phosphocholineapo--[retinol-binding protein]+an all-trans-retinyl ester+a 2-acyl-sn-glycero-3-phosphocholine
Catalysed by LRAT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:17469CC BY 4.0Reference data
all-trans-retinol+1,2-dihexadecanoyl-sn-glycero-3-phosphocholineall-trans-retinyl hexadecanoate+2-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by LRAT
Reaction pageLeft to rightBalanced
Rhea RHEA:43904CC BY 4.0Reference data
1,2-diheptanoyl-sn-glycero-3-phosphocholine+all-trans-retinol--[retinol-binding protein]CHEBI:138724+CHEBI:138266+apo--[retinol-binding protein]
Catalysed by LRAT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:55320CC BY 4.0Reference data
1,2-dioctanoyl-sn-glycero-3-phosphocholine+all-trans-retinol--[retinol-binding protein]2-octanoyl-sn-glycero-3-phosphocholine+all-trans-retinyl octanoate+apo--[retinol-binding protein]
Catalysed by LRAT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:56240CC BY 4.0Reference data
all-trans-retinol--[retinol-binding protein]+1,2-dihexadecanoyl-sn-glycero-3-phosphocholineapo--[retinol-binding protein]+all-trans-retinyl hexadecanoate+2-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by LRAT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:56244CC BY 4.0Reference data
CHEBI:65211+all-trans-retinol--[retinol-binding protein]CHEBI:140088+CHEBI:140089+apo--[retinol-binding protein]
Catalysed by LRAT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:56248CC BY 4.0Reference data