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Proteins/UNIPROT:P41227
Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development. Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX. Acetylates HIST1H4A. Acts as a negative regulator of sister chromatid cohesion during mitosis..
Function from UniProtKB (P41227), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 rows
127 statements
127 statements · 5 reference databases · Subject: NAA10 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM
9 reactions
CHEBI:1146900+proton+MAM02538cCHEBI:15351+CHEBI:15650
Catalysed by LPCAT2 or NAT14 or SH3GLB1 or ZDHHC8 or NAA10 or ZDHHC15 or ZDHHC2 or NAT9 or NAA40 or LPCAT3 or NAA60 or MBOAT7 and 20 more alternatives
6 names
Resolves to: NAA10
Human-GEM MAR01088CC BY 4.0Reference data
CHEBI:1146900+proton+MAM02538nCHEBI:15351+CHEBI:15650
Catalysed by ZDHHC6 or LPCAT2 or NAT14 or SH3GLB1 or ZDHHC8 or NAA10 or PORCN or ZDHHC15 or PLA2G15 or ZDHHC2 or NAA60 or PLAAT2 and 21 more alternatives
Reaction pageReversibleBalancedEC 2.3.1.-nucleus
Human-GEM MAR01091CC BY 4.0Reference data
MAM01259c+CHEBI:1146900+protonCHEBI:15351+CHEBI:15727
Catalysed by NAA10
Reaction pageReversibleBalancedEC 2.3.1.255cytosol
Human-GEM MAR04426CC BY 4.0Reference data
N-terminal glycyl-[protein]+acetyl-CoAN-terminal N(alpha)-acetylglycyl-[protein]+coenzyme A(4-)+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:50496CC BY 4.0Reference data
N-terminal L-alanyl-[protein]+acetyl-CoAN-terminal N(alpha)-acetyl-L-alanyl-[protein]+coenzyme A(4-)+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:50500CC BY 4.0Reference data
N-terminal L-seryl-[protein]+acetyl-CoAN-terminal N(alpha)-acetyl-L-seryl-[protein]+coenzyme A(4-)+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:50504CC BY 4.0Reference data
N-terminal L-valyl-[protein]+acetyl-CoAN-terminal N(alpha)-acetyl-L-valyl-[protein]+coenzyme A(4-)+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:50508CC BY 4.0Reference data
N-terminal L-cysteinyl-[protein]+acetyl-CoAN-terminal N(alpha)-acetyl-L-cysteinyl-[protein]+coenzyme A(4-)+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:50512CC BY 4.0Reference data
N-terminal L-threonyl-[protein]+acetyl-CoAN-terminal N(alpha)-acetyl-L-threonyl-[protein]+coenzyme A(4-)+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:50516CC BY 4.0Reference data