Loading the page.
Proteins/UNIPROT:P17174
Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway..
Function from UniProtKB (P17174), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
177 statements
177 statements · 9 reference databases · Subject: GOT1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
12 reactions
2-oxoglutarate(2-)+L-aspartateL-glutamate(1-)+oxaloacetate
Reaction pageReversibleBalancedEC 2.6.1.1cytosol
Human-GEM MAR03829CC BY 4.0Reference data
3-sulfino-L-alanine+2-oxoglutarate(2-)+proton3-sulfinopyruvate+L-glutamate(1-)
Catalysed by GOT1
6 names
Resolves to: GOT1
Human-GEM MAR03861CC BY 4.0Reference data
2-oxoglutarate(2-)+L-cysteineL-glutamate(1-)+2-oxo-3-sulfanylpropanoate
Reaction pageReversibleBalancedEC 2.6.1.1, 2.6.1.3cytosol
Human-GEM MAR03912CC BY 4.0Reference data
2-oxoglutarate(2-)+MAM02358m4-hydroxy-2-oxoglutaric acid+L-glutamate(1-)
Reaction pageLeft to rightBalancedEC 2.6.1.1, 2.6.1.23mitochondrial matrix
Human-GEM MAR04786CC BY 4.0Reference data
2-oxoglutarate(2-)+L-phenylalanineL-glutamate(1-)+3-phenylpyruvate
Catalysed by GOT1 or GOT2 or TAT
Reaction pageReversibleBalancedEC 2.6.1.1, 2.6.1.5, 2.6.1.57cytosol
Human-GEM MAR06725CC BY 4.0Reference data
2-oxoglutarate(2-)+CHEBI:178953-(4-hydroxyphenyl)pyruvate+L-glutamate(1-)
Catalysed by GOT1 or GOT2 or TAT
Reaction pageLeft to rightBalancedEC 2.6.1.1, 2.6.1.5, 2.6.1.57cytosol
Human-GEM MAR06768CC BY 4.0Reference data
MAM00920c+L-glutamate(1-)2-oxoglutarate(2-)+MAM02350c
Reaction pageReversibleBalancedEC 2.6.1.1, 2.6.1.3cytosol
Human-GEM MAR08066CC BY 4.0Reference data
2-oxoglutarate(2-)+MAM02358c4-hydroxy-2-oxoglutaric acid+L-glutamate(1-)
Catalysed by GOT1
Reaction pageLeft to rightBalancedEC 2.6.1.1cytosol
Human-GEM MAR11399CC BY 4.0Reference data
L-cysteine+2-oxoglutarate(2-)2-oxo-3-sulfanylpropanoate+L-glutamate(1-)
Reaction pageReversibleBalanced
Rhea RHEA:17441CC BY 4.0Reference data
L-aspartate+2-oxoglutarate(2-)oxaloacetate+L-glutamate(1-)
Catalysed by GOT2 or GOT1 or GOT1L1
Reaction pageLeft to rightBalanced
Rhea RHEA:21824CC BY 4.0Reference data
(2S)-2-aminobutanoate+2-oxoglutarate(2-)2-oxobutanoate+L-glutamate(1-)
Catalysed by GOT1
Reaction pageRight to leftBalanced
Rhea RHEA:70223CC BY 4.0Reference data
3-sulfino-L-alanine+2-oxoglutarate(2-)3-sulfinopyruvate+L-glutamate(1-)
Catalysed by GOT1
Reaction pageRight to leftBalanced
Rhea RHEA:70295CC BY 4.0Reference data