ferricytochrome c

Three steps

• N-(acetyl)-sphing-4-enineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate

  Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, cytosol, extracellular space

• (5-hydroxyindol-3-yl)acetaldehydeReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. Transport of 5-Hydroxyindoleacetate
  3. (5-hydroxyindol-3-yl)acetaldehyde + NAD(+) + H2O = (5-hydroxyindol-3-yl)acetate + NADH + 2 H(+)

  Catalysed by SUOX, SLC4A1, ALDH9A1mitochondrial matrix, cytosol, extracellular space

• gamma-Glu-AlaReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by LDHD, AGXT2, GGT1, GGT5 and 4 moremitochondrial matrix, cytosol, extracellular space

• taurineReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by SUOX, SLC26A6, SLC6A6mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• acetoacetyl-CoAReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate

  Catalysed by LDHD, AACSmitochondrial matrix, cytosolOne of 2 routes

• glycineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-Alanine:glyoxylate aminotransferase

  Catalysed by LDHD, AGXT2, AGXTmitochondrial matrix, cytosolOne of 17 routes

• (S)-malyl-CoAReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate

  Catalysed by LDHD, ME2, SUCLG1, SUCLA2mitochondrial matrix, cytosol

• (R)-methylmalonyl-CoAReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by LDHD, AGXT2, ALDH6A1mitochondrial matrix, cytosol

• butanoyl-CoAReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. transport of butyrate and pyruvate (cytosol to extracellular)
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A3 and 9 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• propanoyl-CoAReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
  3. 2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+)

  Catalysed by LDHD, AGXT2, ALDH6A1mitochondrial matrix, cytosol

• prostaglandin E1Reach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. prostaglandin E1(out) + 2 (S)-lactate(in) = prostaglandin E1(in) + 2 (S)-lactate(out)

  Catalysed by LDHD, LDHA, LDHB, LDHC and 3 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin F2alphaReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. prostaglandin F2alpha(out) + 2 (S)-lactate(in) = prostaglandin F2alpha(in) + 2 (S)-lactate(out)

  Catalysed by LDHD, LDHA, LDHB, LDHC and 3 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• prostaglandin H2Reach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)

  Catalysed by LDHD, LDHA, LDHB, LDHC and 3 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin D2Reach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. prostaglandin D2(out) + 2 (S)-lactate(in) = prostaglandin D2(in) + 2 (S)-lactate(out)

  Catalysed by LDHD, LDHA, LDHB, LDHC and 3 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-alanineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by LDHD, AGXT2, SLC7A10mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 7,8-dihydrofolateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. Folate Transport by Oats
  3. dihydrofolate:NAD+ oxidoreductase

  Catalysed by SUOX, SLC22A8, SLC22A7, DHFR and 1 moremitochondrial matrix, cytosol, extracellular spaceOne of 3 routes

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by SUOX, SLC25A10, ASLmitochondrial matrix, cytosolOne of 4 routes

• N-acetyl-D-glucosamine 6-phosphateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate

  Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, cytosol, extracellular space

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

  Catalysed by SUOX, SLC25A10, ADSL, TNRC6Bmitochondrial matrix, cytosolOne of 4 routes

• guanidinoacetateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by SUOX, SLC26A6mitochondrial matrix, cytosol, extracellular space

• 3',5'-cyclic GMPReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)

  Catalysed by SUOX, SLC25A35, SLC25A34, SLC22A6mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-threonineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

  Catalysed by LDHD, AGXT2, SLC7A10mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• CMP-N-acetyl-beta-neuraminateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. CTP:N-acetylneuraminate cytidylyltransferase

  Catalysed by LDHD, NPL, CMASmitochondrial matrix, cytosol, nucleusOne of 2 routes

• adenosine 5'-phosphoramidateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. ATP:sulfate adenylyltransferase
  3. adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + sulfate + 2 H(+)

  Catalysed by SUOX, PAPSS1, PAPSS2, FHITmitochondrial matrix, cytosol

• L-tryptophanReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and tryptophan (cytosol to extracellular)

  Catalysed by LDHD, AGXT2, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 12 routes

• glutathioneReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SUOX, SLC25A14, SLC25A30, TSTD1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-threonineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

  Catalysed by LDHD, AGXT2, SLC7A10mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 5 routes

• L-kynurenineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by LDHD, AGXT2, KYNUmitochondrial matrix, cytosol

• beta-alanineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

  Catalysed by LDHD, AGXT2, SLC7A10mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-hydroxy-3-oxopropanoateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. L-Serine:pyruvate aminotransferase
  3. hydroxypyruvate aldose-ketose-isomerase

  Catalysed by LDHD, AGXT, HYImitochondrial matrix, cytosolOne of 2 routes

• L-asparagineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and asparagine (cytosol to extracellular)

  Catalysed by LDHD, AGXT2, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 13 routes

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by SUOX, SLC25A14, SLC25A30, AGAmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• L-phenylalanineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and phenylalanine (cytosol to extracellular)

  Catalysed by LDHD, AGXT2, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 16 routes

• 3-hydroxy-L-kynurenineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by LDHD, AGXT2, KYNUmitochondrial matrix, cytosol

• 3',5'-cyclic AMPReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out)

  Catalysed by SUOX, SLC25A35, SLC25A34, SLC22A6mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-homocysteineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by LDHD, TYW1B, TYW1, BHMT2mitochondrial matrix, cytosol

• S-methyl-L-methionineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by LDHD, TYW1B, TYW1, BHMT2mitochondrial matrix, cytosol

• N-acetylputrescineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, cytosol, extracellular space

• (2R)-2-phosphoglycerateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. pyruvate kinase (dTDP)
  3. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)

  Catalysed by LDHD, PKM, PKLR, ENO1 and 2 moremitochondrial matrix, cytosol

• glutathione disulfideReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by GPX1, GSTA1, GPX2, GPX4cytosolOne of 2 routes

• L-tyrosineReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)

  Catalysed by SUOX, SLC25A14, SLC25A30, SLC7A13mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by LDHD, AGXT2mitochondrial matrix, cytosolOne of 8 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by LDHD, AGXT2, SLC1A4mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by SUOX, SLC25A10, ADSLmitochondrial matrix, cytosolOne of 4 routes

• kynurenateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O

  Catalysed by LDHD, MPST, AADATmitochondrial matrix, cytosolOne of 4 routes

• N(8)-acetylspermidineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(8)-acetylspermidine + H2O = spermidine + acetate

  Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, cytosol, extracellular space

• (S)-3-amino-2-methylpropanoateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-3-amino-isobutanoate:2-oxoglutarate aminotransferase

  Catalysed by LDHD, AGXT2, ABATmitochondrial matrix, cytosol

• phosphoenolpyruvateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. Pyruvate:carbon-dioxide ligase (ADP-forming)
  3. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2

  Catalysed by LDHD, PC, PCK1, PCK2mitochondrial matrix, cytosol

• an N-acetyl-L-cysteine-S-conjugateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate

  Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, cytosol, extracellular space

• D-glucosamineReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by SUOX, SGSHmitochondrial matrix, cytosol