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Proteins/UNIPROT:P30613
Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis. Also produces the side product 2-phospholactate which can inhibit fructose-2,6-bisphosphate production. 2-phospholactate can be dephosphorylated by PGP which prevents the inhibition of fructose-2,6-bisphosphate production and allows glycolysis to occur..
Function from UniProtKB (P30613), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
42 statements
42 statements · 6 reference databases · Subject: PKLR · Sources: Hetionet, Human Protein Atlas, Human-GEM, Rhea, UniProt, WikiPathways
9 reactions
GDP+proton+phosphoenolpyruvic acidGTP+pyruvate
Reaction pageLeft to rightBalancedEC 2.7.1.40cytosol
Human-GEM MAR04171CC BY 4.0Reference data
CHEBI:17239+proton+phosphoenolpyruvic acidCHEBI:17677+pyruvate
Catalysed by
6 names
Resolves to: PKLR
Reaction pageLeft to rightBalancedEC 2.7.1.40cytosol
Human-GEM MAR04193CC BY 4.0Reference data
proton+phosphoenolpyruvic acid+UDPpyruvate+UTP
Reaction pageLeft to rightBalancedEC 2.7.1.40cytosol
Human-GEM MAR04210CC BY 4.0Reference data
ADP+proton+phosphoenolpyruvic acidATP+pyruvate
Reaction pageLeft to rightBalancedEC 2.7.1.40cytosol
Human-GEM MAR04358CC BY 4.0Reference data
CHEBI:16174+proton+phosphoenolpyruvic acidCHEBI:16284+pyruvate
Reaction pageLeft to rightBalancedEC 2.7.1.40cytosol
Human-GEM MAR04421CC BY 4.0Reference data
CHEBI:28862+proton+phosphoenolpyruvic acidCHEBI:16497+pyruvate
Reaction pageLeft to rightBalancedEC 2.7.1.40cytosol
Human-GEM MAR04573CC BY 4.0Reference data
dTDP+proton+phosphoenolpyruvic aciddTTP+pyruvate
Reaction pageReversibleBalancedEC 2.7.1.40cytosol
Human-GEM MAR06627CC BY 4.0Reference data
pyruvate+ATP(4-)phosphoenolpyruvate+ADP(3-)+hydron
Reaction pageRight to leftBalanced
Rhea RHEA:18157CC BY 4.0Reference data
(S)-lactate+ATP(4-)(2S)-2-phospholactate+ADP(3-)+hydron
Catalysed by PKLR
Reaction pageDirection not assertedBalanced
Rhea RHEA:86567CC BY 4.0Reference data