Loading the page.
Proteins/UNIPROT:P53597
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits (By similarity). Also able to act as an itaconyl- and malyl-CoA synthetase..
Function from UniProtKB (P53597), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
340 statements
340 statements · 7 reference databases · Subject: SUCLG1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
9 reactions
CHEBI:1146900+GTP+succinate(2-)GDP+phosphate(3-)+CHEBI:15380
Catalysed by SUCLG1 & SUCLG2 or SUCLG1 & SUCLA2
Reaction pageReversibleBalancedEC 6.2.1.4mitochondrial matrix
Human-GEM MAR04147CC BY 4.0Reference data
4 names
Resolves to: SUCLG1
Reaction pageReversibleBalancedEC 6.2.1.5mitochondrial matrix
Human-GEM MAR04152CC BY 4.0Reference data
CHEBI:1146900+GTP+itaconateGDP+itaconyl-CoA+phosphate(3-)
Catalysed by SUCLG1 & SUCLG2 or SUCLG1 & SUCLA2
Reaction pageReversibleBalancedEC 6.2.1.5mitochondrial matrix
Human-GEM MAR08662CC BY 4.0Reference data
ADP+itaconyl-CoA+phosphate(3-)ATP+CHEBI:1146900+itaconate
Catalysed by SUCLG1 & SUCLG2 or SUCLG1 & SUCLA2
Reaction pageReversibleBalancedEC 6.2.1.5mitochondrial matrix
Human-GEM MAR08663CC BY 4.0Reference data
ADP+MAM02466m+phosphate(3-)ATP+CHEBI:1146900+MAM02465m
Catalysed by SUCLG1 & SUCLG2 or SUCLG1 & SUCLA2
Reaction pageReversibleBalancedEC 6.2.1.5mitochondrial matrix
Human-GEM MAR08667CC BY 4.0Reference data
CHEBI:1146900+GTP+MAM02465mGDP+MAM02466m+phosphate(3-)
Catalysed by SUCLG1 & SUCLG2 or SUCLG1 & SUCLA2
Reaction pageReversibleBalancedEC 6.2.1.5mitochondrial matrix
Human-GEM MAR08668CC BY 4.0Reference data
succinate(2-)+ATP(4-)+coenzyme A(4-)succinyl-CoA+ADP(3-)+hydrogenphosphate
Reaction pageDirection not assertedBalanced
Rhea RHEA:17661CC BY 4.0Reference data
GTP+succinate(2-)+coenzyme A(4-)succinyl-CoA+GDP+hydrogenphosphate
Reaction pageDirection not assertedBalanced
Rhea RHEA:22120CC BY 4.0Reference data
(S)-malate+ATP(4-)+coenzyme A(4-)(S)-malyl-CoA+ADP(3-)+hydrogenphosphate
Reaction pageDirection not assertedBalanced
Rhea RHEA:26193CC BY 4.0Reference data