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Proteins/UNIPROT:Q86WU2
The mitochondrial D-lactate dehydrogenase is a stereoselective dehydrogenase that targets a wide variety of D-2-hydroxyacids, particularly those with small to moderately sized hydrophobic groups attached to the C2 atom. It includes D-lactate which is generated in small amounts either endogenously through the methylglyoxal metabolism pathway or exogenously via intestinal bacterial activity and dietary intake. The dehydrogenase acts specifically on D-lactate, not on its stereoisomer L-lactate, and prevents the toxic accumulation of D-lactate in the organism. By converting branched-chain D-2-hydroxyacids into branched-chain ketoacids, it may indirectly regulate branched-chain amino acid metabolism (By similarity)..
Function from UniProtKB (Q86WU2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
59 statements
59 statements · 8 reference databases · Subject: LDHD · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
16 reactions
3proton+23-hydroxypyruvic acid+NADH(2-)NAD(+)+2MAM03620c
Catalysed by LDHB or LDHA or LDHC or LDHAL6A or LDHD or LDHAL6B
Reaction pageLeft to rightUnbalancedEC 1.1.1.27cytosol
Human-GEM MAR01453CC BY 4.0Reference data
2 names
Resolves to: LDHD
Catalysed by LDHD
Reaction pageLeft to rightBalancedEC 1.1.2.4cytosol, mitochondrial matrix
Human-GEM MAR03859CC BY 4.0Reference data
(R)-lactic acid+NAD(+)proton+NADH(2-)+pyruvate
Catalysed by LDHD
Reaction pageReversibleBalancedEC 1.1.2.4cytosol
Human-GEM MAR08512CC BY 4.0Reference data
glyoxylic acid+water+NAD(+)2proton+NADH(2-)+oxalic acid
Catalysed by LDHB or LDHC or LDHAL6A or LDHD or LDHAL6B
Reaction pageLeft to rightBalancedEC 1.1.1.27cytosol
Human-GEM MAR08780CC BY 4.0Reference data
3-methyl-2-oxovaleric acid+proton+NADH(2-)NAD(+)+MAM03176c
Catalysed by LDHB or LDHA or LDHC or LDHD or LDHAL6B
Reaction pageReversibleBalancedEC 1.1.1.27cytosol
Human-GEM MAR11476CC BY 4.0Reference data
3-methyl-2-oxobutanoate+proton+NADH(2-)NAD(+)+MAM03186c
Catalysed by LDHB or LDHA or LDHC or LDHAL6A or LDHD or LDHAL6B
Reaction pageReversibleBalancedEC 1.1.1.27cytosol
Human-GEM MAR11479CC BY 4.0Reference data
(R)-lactate+FAD(3-)+hydronFADH2(2-)+pyruvate
Catalysed by LDHD
Reaction pageLeft to rightBalanced
Rhea RHEA:82479CC BY 4.0Reference data
(2R)-hydroxybutanoate+FAD(3-)+hydron2-oxobutanoate+FADH2(2-)
Catalysed by LDHD
Reaction pageLeft to rightBalanced
Rhea RHEA:82483CC BY 4.0Reference data
(2R)-hydroxypentanoate+FAD(3-)+hydron2-oxopentanoate+FADH2(2-)
Catalysed by LDHD
Reaction pageLeft to rightBalanced
Rhea RHEA:82487CC BY 4.0Reference data
(2R)-hydroxyhexanoate+FAD(3-)+hydron2-oxohexanoate+FADH2(2-)
Catalysed by LDHD
Reaction pageLeft to rightBalanced
Rhea RHEA:82491CC BY 4.0Reference data
CHEBI:232387+FAD(3-)+hydronCHEBI:176689+FADH2(2-)
Catalysed by LDHD
Reaction pageLeft to rightBalanced
Rhea RHEA:82495CC BY 4.0Reference data
(2R)-hydroxy-4-methylpentanoate+FAD(3-)+hydron4-methyl-2-oxopentanoate+FADH2(2-)
Catalysed by LDHD
Reaction pageLeft to rightBalanced
Rhea RHEA:82499CC BY 4.0Reference data