trans-4-hydroxy-L-proline

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

445 compounds within 3 steps: 4 in 1, 54 in 2, 387 in 3

One step

a quinolReach from here →
1. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)
Catalysed by PRODH2
L-threonineReach from here →
1. trans-4-hydroxy-L-proline(out) + L-threonine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-threonine(out) + Na(+)(in)
Catalysed by SLC1A4inner side of the membrane, outer side of the membraneOne of 2 routes
L-alanineReach from here →
1. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)
Catalysed by SLC1A4inner side of the membrane, outer side of the membraneOne of 2 routes
(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylateReach from here →
1. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)
Catalysed by PRODH2

Two steps

CHEBI:1146900Reach from here →
1. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
Catalysed by SLC1A4inner side of the membrane, outer side of the membrane, mitochondrial matrix
N(omega)-methyl-L-arginineReach from here →
1. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)
2. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine
Catalysed by SLC1A4, AGXT2inner side of the membrane, outer side of the membrane
a quinone

Reach from here →

Catalysed by PRODH2, CYC1, UQCRFS1outer side of the membraneOne of 7 routes

acetaldehydeReach from here →

Catalysed by SLC1A4, SHMT1inner side of the membrane, outer side of the membrane

pyruvateReach from here →

Catalysed by SLC1A4, AGXT2inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 14 routes

CHEBI:15570Reach from here →

Catalysed by SLC1A4inner side of the membrane, outer side of the membrane, cytosol

L-leucineReach from here →

Catalysed by SLC1A4, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

CHEBI:15699Reach from here →

Catalysed by SLC1A4, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

CHEBI:15971Reach from here →

Catalysed by SLC1A4, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

L-cystineReach from here →

Catalysed by SLC1A4, SLC7A9, SLC3A1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

(R)-3-aminoisobutyric acidReach from here →

Catalysed by SLC1A4, AGXT2inner side of the membrane, outer side of the membrane, mitochondrial matrix

L-citrullineReach from here →

Catalysed by SLC1A4, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

L-valineReach from here →

Catalysed by SLC1A4, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 6 routes

L-arginineReach from here →

Catalysed by SLC1A4, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

protein polypeptide chainReach from here →

Catalysed by SLC1A4inner side of the membrane, outer side of the membrane, cytosol

CHEBI:16633Reach from here →

Catalysed by SLC1A4, SCLYinner side of the membrane, outer side of the membrane, cytosol

2-oxobutanoateReach from here →

Catalysed by SLC1A4, SDS, SDSLinner side of the membrane, outer side of the membrane

CHEBI:16857Reach from here →

Catalysed by SLC1A4, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

L-isoleucineReach from here →

Catalysed by SLC1A4, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

CHEBI:17203Reach from here →

Catalysed by SLC1A4, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

AH2Reach from here →

Catalysed by SLC1A4, MOCOSinner side of the membrane, outer side of the membrane

L-cysteineReach from here →

Catalysed by SLC1A4, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 11 routes

Ala-tRNA(Ala)Reach from here →

Catalysed by SLC1A4, AARS1inner side of the membrane, outer side of the membrane, cytosol

CHEBI:17895Reach from here →

Catalysed by SLC1A4, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

CHEBI:18019Reach from here →

Catalysed by SLC1A4, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

L-glutamineReach from here →

Catalysed by SLC1A4, SLC3A2, SLC7A5, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 10 routes

CHEBI:18095Reach from here →

Catalysed by SLC1A4inner side of the membrane, outer side of the membrane, extracellular space, cytosol

2-aminoisobutanoateReach from here →

Catalysed by SLC1A4, SLC7A10inner side of the membrane, outer side of the membraneOne of 2 routes

N(omega),N('omega)-dimethyl-L-arginineReach from here →

Catalysed by SLC1A4, AGXT2inner side of the membrane, outer side of the membrane

pyridoxine 5'-phosphateReach from here →

Catalysed by SLC1A4, SCLYinner side of the membrane, outer side of the membrane, cytosol

chlorine(.)Reach from here →

Catalysed by SLC1A4, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

L-aspartateReach from here →

Catalysed by SLC1A4, AGXT2inner side of the membrane, outer side of the membrane

(S)-dihydroorotateReach from here →

Catalysed by PRODH2, DHODH

D-cysteineReach from here →

Catalysed by SLC1A4, SLC7A10inner side of the membrane, outer side of the membraneOne of 2 routes

D-serineReach from here →

Catalysed by SLC1A4, SLC7A10inner side of the membrane, outer side of the membraneOne of 6 routes

L-ornithineReach from here →

Catalysed by SLC1A4, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

gamma-Glu-AlaReach from here →

Catalysed by SLC1A4, GGT1, GGT5, GGTLC2 and 3 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamideReach from here →

Catalysed by PRODH2, NQO2

glycineReach from here →

Catalysed by SLC1A4, AGXT, AGXT2inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 10 routes

D-alanineReach from here →

Catalysed by SLC1A4, SLC7A10inner side of the membrane, outer side of the membraneOne of 2 routes

D-threonineReach from here →

Catalysed by SLC1A4, SLC7A10inner side of the membrane, outer side of the membraneOne of 2 routes

L-methionineReach from here →

Catalysed by SLC1A4, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 7 routes

L-tryptophanReach from here →

Catalysed by SLC1A4, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

L-kynurenineReach from here →

Catalysed by SLC1A4, KYNUinner side of the membrane, outer side of the membrane

beta-alanineReach from here →

Catalysed by SLC1A4, SLC7A10inner side of the membrane, outer side of the membraneOne of 2 routes

L-asparagineReach from here →

Catalysed by SLC1A4, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 6 routes