Loading the page.
Proteins/UNIPROT:P30566
Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate..
Function from UniProtKB (P30566), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
95 statements
95 statements · 7 reference databases · Subject: ADSL · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
AMP+fumaric acidN(6)-(1,2-dicarboxyethyl)-AMP
Reaction pageReversibleBalancedEC 4.3.2.2cytosol
Human-GEM MAR04412CC BY 4.0Reference data
5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide+fumaric acid(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate
Catalysed by ADSL
Reaction pageReversibleBalancedEC 4.3.2.2cytosol
4 names
Resolves to: ADSL
N(6)-(1,2-dicarboxyethyl)-AMPfumaric acid+AMP
Catalysed by ADSL
Reaction pageDirection not assertedBalanced
Rhea RHEA:16853CC BY 4.0Reference data
(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide+fumaric acid
Catalysed by ADSL
Reaction pageDirection not assertedBalanced
Rhea RHEA:23920CC BY 4.0Reference data