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Proteins/UNIPROT:P25325
Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions..
Function from UniProtKB (P25325), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
81 statements
81 statements · 7 reference databases · Subject: MPST · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
5 reactions
proton+2-oxo-3-sulfanylpropanoate+sulfitethiosulfate+pyruvate
Reaction pageLeft to rightBalancedEC 2.8.1.2cytosol
Human-GEM MAR03928CC BY 4.0Reference data
2-oxo-3-sulfanylpropanoate+sulfitepyruvate+thiosulfate
Catalysed by MPST or
2 names
Resolves to: MPST
Reaction pageLeft to rightBalancedEC 2.8.1.2cytosol
Human-GEM MAR06515CC BY 4.0Reference data
hydrogen cyanide+2-oxo-3-sulfanylpropanoateproton+pyruvate+thiocyanate
Reaction pageLeft to rightBalancedEC 2.8.1.2cytosol
Human-GEM MAR06518CC BY 4.0Reference data
hydrogen cyanide+thiosulfateproton+sulfite+thiocyanate
Reaction pageReversibleBalancedEC 2.8.1.1mitochondrial matrix
Human-GEM MAR06520CC BY 4.0Reference data
2-oxo-3-sulfanylpropanoate+[thioredoxin]-dithiol[thioredoxin]-disulfide+hydrogen sulfide+pyruvate+hydron
Catalysed by MPST
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:21740CC BY 4.0Reference data