N(omega),N(omega)-dimethyl-L-arginine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

591 compounds within 3 steps: 12 in 1, 132 in 2, 447 in 3

One step

L-citrullineReach from here →
1. Nomega,Nomega'-dimethyl-L-arginine dimethylamidohydrolase
Catalysed by DDAH1cytosolOne of 2 routes
L-arginineReach from here →
1. N(omega),N(omega)-dimethyl-L-arginine(in) + L-arginine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-arginine(in)
Catalysed by SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes
5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
Catalysed by AGXT2One of 6 routes
L-aspartateReach from here →
1. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
Catalysed by AGXT2
L-lysineReach from here →
1. N(omega),N(omega)-dimethyl-L-arginine(in) + L-lysine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-lysine(in)
Catalysed by SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes
L-ornithineReach from here →
1. N(omega),N(omega)-dimethyl-L-arginine(in) + L-ornithine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-ornithine(in)
Catalysed by SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes
glycineReach from here →
1. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
Catalysed by AGXT2
L-alanineReach from here →
1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
Catalysed by AGXT2
dimethylamineReach from here →
1. Nomega,Nomega'-dimethyl-L-arginine dimethylamidohydrolase
Catalysed by DDAH1cytosolOne of 2 routes
L-2-aminopentanoateReach from here →
1. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate
Catalysed by AGXT2
L-2-aminohexanoateReach from here →
1. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate
Catalysed by AGXT2
(2S)-2-aminobutanoateReach from here →
1. N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate
Catalysed by AGXT2

Two steps

CHEBI:1146900Reach from here →
1. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
Catalysed by AGXT2mitochondrial matrixOne of 30 routes
N(omega)-methyl-L-arginineReach from here →
1. N(omega),N(omega)-dimethyl-L-arginine(in) + L-arginine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-arginine(in)
2. N(omega)-methyl-L-arginine(in) + L-arginine(out) = N(omega)-methyl-L-arginine(out) + L-arginine(in)
Catalysed by SLC25A2, SLC25A29inner side of the membrane, outer side of the membraneOne of 4 routes
glycoursodeoxycholate

Reach from here →

Catalysed by AGXT2cytosolOne of 2 routes

epsilon-(gamma-L-glutamyl)-L-lysineReach from here →

Catalysed by SLC25A2, GGACTinner side of the membrane, outer side of the membrane

N-(9Z-octadecenoyl)glycineReach from here →

Catalysed by AGXT2, GLYATL3, GLYATL2

N-octadecanoylglycineReach from here →

Catalysed by AGXT2, GLYATL2

N-(9Z-hexadecenoyl)-glycineReach from here →

Catalysed by AGXT2, GLYATL2

N-hexadecanoylglycineReach from here →

Catalysed by AGXT2, GLYATL3

N-dodecanoylglycineReach from here →

Catalysed by AGXT2, GLYATL2

N-decanoylglycineReach from here →

Catalysed by AGXT2, GLYATL2

N-octanoylglycineReach from here →

Catalysed by AGXT2, GLYATL2

D-histidineReach from here →

Catalysed by SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes

L-homoarginineReach from here →

Catalysed by SLC25A2, SLC25A29inner side of the membrane, outer side of the membraneOne of 4 routes

N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →

Catalysed by AGXT2, GART

L-cystine-bis-glycineReach from here →

Catalysed by AGXT2, DPEP1, DPEP2

glycyldehydrophenylalanineReach from here →

Catalysed by AGXT2, DPEP1

an N-(fatty acyl)-glycineReach from here →

Catalysed by AGXT2, GLYATL2

N-(9Z,12Z-octadecadienoyl)-glycineReach from here →

Catalysed by AGXT2, GLYATL2

pyruvateReach from here →

Catalysed by AGXT2One of 15 routes

CHEBI:15570Reach from here →

Catalysed by AGXT2cytosolOne of 3 routes

L-leucineReach from here →

Catalysed by DDAH1cytosol, extracellular spaceOne of 25 routes

CHEBI:15611Reach from here →

Catalysed by AGXT2, GNMTcytosol

CHEBI:15699Reach from here →

Catalysed by DDAH1, SLC7A9, SLC3A1, SLC7A6cytosol, extracellular spaceOne of 12 routes

N-carbamoyl-L-aspartic acidReach from here →

Catalysed by AGXT2, CADcytosol

CHEBI:15971Reach from here →

Catalysed by DDAH1, SLC7A5, SLC7A6cytosol, extracellular spaceOne of 18 routes

sulfateReach from here →

Catalysed by AGXT2, SLC25A14, SLC25A30inner side of the membrane, outer side of the membraneOne of 2 routes

ureaReach from here →

Catalysed by SLC25A2, ARG1inner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

L-cystineReach from here →

Catalysed by SLC25A2, SLC7A9inner side of the membrane, outer side of the membraneOne of 4 routes

(R)-3-aminoisobutyric acidReach from here →

Catalysed by AGXT2mitochondrial matrix

L-valineReach from here →

Catalysed by DDAH1, SLC7A9, SLC3A1, SLC7A6cytosol, extracellular spaceOne of 17 routes

oxaloacetateReach from here →

Catalysed by AGXT2One of 6 routes

nitric oxideReach from here →

Catalysed by SLC25A2, NOS3, NOS1, NOS2inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

CHEBI:16523Reach from here →

Catalysed by AGXT2, SLC3A2, SLC7A10extracellular space, cytosolOne of 2 routes

protein polypeptide chainReach from here →

Catalysed by SLC25A2inner side of the membrane, outer side of the membrane, cytosolOne of 4 routes

N(2)-acetyl-L-ornithineReach from here →

Catalysed by SLC25A2, ACY1inner side of the membrane, outer side of the membrane, cytosol

CHEBI:16633Reach from here →

Catalysed by AGXT2, SCLYcytosol

2-oxobutanoateReach from here →

Catalysed by AGXT2One of 4 routes

CHEBI:16856Reach from here →

Catalysed by AGXT2, GSScytosol