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Proteins/UNIPROT:P36269
Cleaves the gamma-glutamyl bond of extracellular glutathione tripeptide (gamma-Glu-Cys-Gly) and certain glutathione conjugates. Hydrolyzes glutathione releasing L-Glu and Cys-Gly dipeptide which is further metabolized to maintain extracellular cysteine levels but also to provide cysteine necessary for intracellular glutathione synthesis. Among glutathione-S-conjugates metabolizes leukotriene C4 (LTC4) and S-geranylgeranyl-glutathione (GGG), but is inactive toward gamma-glutamyl leucine. Converts extracellular LTC4 to LTD4 during acute inflammatory response. Acts as a negative regulator of GGG bioactivity. GGT5 (via GGG catabolism) and ABCC1 (via extracellular transport) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to bone marrow parenchyma (By similarity). The transpeptidation reaction, i.e. the transfer of gamma-glutamyl moiety to an acceptor molecule to yield a new gamma-glutamyl compound requires high concentration of dipeptide acceptor and is considered nonphysiological..
Function from UniProtKB (P36269), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
60 statements
60 statements · 6 reference databases · Subject: GGT5 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
16 reactions
proton+leukotriene C4MAM01111e+CHEBI:28666
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGTLC1 or GGT6
Reaction pageLeft to rightBalancedEC 2.3.2.2extracellular space
Human-GEM MAR01084CC BY 4.0Reference data
water+MAM02367cL-glutamate(1-)+MAM02368c
Catalysed by
9 names
Resolves to: GGT5
Reaction pageReversibleBalancedEC 2.3.2.2cytosol
Human-GEM MAR02556CC BY 4.0Reference data
CHEBI:16856+waterL-cysteinylglycine+L-glutamate(1-)
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGT6 or GGTLC3
Reaction pageLeft to rightBalancedEC 2.3.2.2, 3.4.11.4cytosol
Human-GEM MAR04175CC BY 4.0Reference data
CHEBI:16856+waterL-cysteinylglycine+L-glutamate(1-)
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGT6 or GGTLC3
Reaction pageLeft to rightBalancedEC 2.3.2.2, 3.4.11.4extracellular space
Human-GEM MAR04176CC BY 4.0Reference data
water+leukotriene C4L-glutamate(1-)+CHEBI:28666
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGT6 or GGTLC3
Reaction pageLeft to rightBalancedEC 2.3.2.2cytosol
Human-GEM MAR04796CC BY 4.0Reference data
L-alanine+CHEBI:16856L-cysteinylglycine+MAM01930c
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGT6 or GGTLC3
Reaction pageReversibleBalancedEC 2.3.2.2cytosol
Human-GEM MAR04937CC BY 4.0Reference data
water+leukotriene C4L-glutamate(1-)+CHEBI:28666
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGTLC1 or GGT6
Reaction pageReversibleBalancedEC 2.3.2.2endoplasmic reticulum
Human-GEM MAR08548CC BY 4.0Reference data
L-alanine+CHEBI:16856gamma-Glu-Ala+L-cysteinylglycine
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGTLC1 or GGT6
Reaction pageLeft to rightBalancedEC 2.3.2.2cytosol, extracellular space
Human-GEM MAR08769CC BY 4.0Reference data
MAM01926e+waterL-glutamate(1-)+proton+MAM02326e
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGT6 or GGTLC3
Reaction pageLeft to rightBalancedEC 2.3.2.2extracellular space
Human-GEM MAR09571CC BY 4.0Reference data
L-glutamate(1-)+2proton+MAM02326ecarbon dioxide+MAM01925e+water
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGT6 or GGTLC3
Reaction pageLeft to rightBalancedEC 2.3.2.2extracellular space
Human-GEM MAR09572CC BY 4.0Reference data
MAM01139e+waterL-glutamate(1-)+MAM03282e
Catalysed by GGT5
Reaction pageReversibleBalancedEC 2.3.2.2extracellular space
Human-GEM MAR12014CC BY 4.0Reference data
an N-terminal (5-L-glutamyl)-[peptide]+CHEBI:78608CHEBI:77644+an N-terminal L-alpha-aminoacyl-[peptide]
Catalysed by GGT3P or GGT1 or GGT5 or GGT6 or GGT7
Reaction pageReversibleBalance undeterminable
Rhea RHEA:23904CC BY 4.0Reference data