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Proteins/UNIPROT:P19440
Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate, MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4, LTC4). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4..
[Isoform 3]: Seems to be catalytically inactive..
Function from UniProtKB (P19440), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
127 statements
127 statements · 7 reference databases · Subject: GGT1 · Sources: gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
15 reactions
proton+leukotriene C4MAM01111e+CHEBI:28666
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGTLC1 or GGT6
Reaction pageLeft to rightBalancedEC 2.3.2.2extracellular space
Human-GEM MAR01084CC BY 4.0Reference data
water+MAM02367cL-glutamate(1-)+MAM02368c
Catalysed by
7 names
Resolves to: GGT1
Reaction pageReversibleBalancedEC 2.3.2.2cytosol
Human-GEM MAR02556CC BY 4.0Reference data
CHEBI:16856+waterL-cysteinylglycine+L-glutamate(1-)
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGT6 or GGTLC3
Reaction pageLeft to rightBalancedEC 2.3.2.2, 3.4.11.4cytosol
Human-GEM MAR04175CC BY 4.0Reference data
CHEBI:16856+waterL-cysteinylglycine+L-glutamate(1-)
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGT6 or GGTLC3
Reaction pageLeft to rightBalancedEC 2.3.2.2, 3.4.11.4extracellular space
Human-GEM MAR04176CC BY 4.0Reference data
water+leukotriene C4L-glutamate(1-)+CHEBI:28666
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGT6 or GGTLC3
Reaction pageLeft to rightBalancedEC 2.3.2.2cytosol
Human-GEM MAR04796CC BY 4.0Reference data
L-alanine+CHEBI:16856L-cysteinylglycine+MAM01930c
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGT6 or GGTLC3
Reaction pageReversibleBalancedEC 2.3.2.2cytosol
Human-GEM MAR04937CC BY 4.0Reference data
water+leukotriene C4L-glutamate(1-)+CHEBI:28666
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGTLC1 or GGT6
Reaction pageReversibleBalancedEC 2.3.2.2endoplasmic reticulum
Human-GEM MAR08548CC BY 4.0Reference data
L-alanine+CHEBI:16856gamma-Glu-Ala+L-cysteinylglycine
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGTLC1 or GGT6
Reaction pageLeft to rightBalancedEC 2.3.2.2cytosol, extracellular space
Human-GEM MAR08769CC BY 4.0Reference data
MAM01926e+waterL-glutamate(1-)+proton+MAM02326e
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGT6 or GGTLC3
Reaction pageLeft to rightBalancedEC 2.3.2.2extracellular space
Human-GEM MAR09571CC BY 4.0Reference data
L-glutamate(1-)+2proton+MAM02326ecarbon dioxide+MAM01925e+water
Catalysed by GGT5 or GGT1 or GGTLC2 or GGT7 or GGT6 or GGTLC3
Reaction pageLeft to rightBalancedEC 2.3.2.2extracellular space
Human-GEM MAR09572CC BY 4.0Reference data
an N-terminal (5-L-glutamyl)-[peptide]+CHEBI:78608CHEBI:77644+an N-terminal L-alpha-aminoacyl-[peptide]
Catalysed by GGT3P or GGT1 or GGT5 or GGT6 or GGT7
Reaction pageReversibleBalance undeterminable
Rhea RHEA:23904CC BY 4.0Reference data
glutathione+waterL-cysteinylglycine+L-glutamate(1-)
Catalysed by GGT3P or GGT1 or GGT5 or GGT6 or GGT7
Reaction pageLeft to rightBalanced
Rhea RHEA:28807CC BY 4.0Reference data