Loading the page.
Proteins/UNIPROT:Q9P2R7
ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (By similarity). Also able to act as an ATP-specific itaconyl- and malyl-CoA synthetase..
Function from UniProtKB (Q9P2R7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
155 statements
155 statements · 8 reference databases · Subject: SUCLA2 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
8 reactions
CHEBI:1146900+GTP+succinate(2-)GDP+phosphate(3-)+CHEBI:15380
Catalysed by SUCLG1 & SUCLG2 or SUCLG1 & SUCLA2
Reaction pageReversibleBalancedEC 6.2.1.4mitochondrial matrix
Human-GEM MAR04147CC BY 4.0Reference data
6 names
Resolves to: SUCLA2
Reaction pageReversibleBalancedEC 6.2.1.5mitochondrial matrix
Human-GEM MAR04152CC BY 4.0Reference data
CHEBI:1146900+GTP+itaconateGDP+itaconyl-CoA+phosphate(3-)
Catalysed by SUCLG1 & SUCLG2 or SUCLG1 & SUCLA2
Reaction pageReversibleBalancedEC 6.2.1.5mitochondrial matrix
Human-GEM MAR08662CC BY 4.0Reference data
ADP+itaconyl-CoA+phosphate(3-)ATP+CHEBI:1146900+itaconate
Catalysed by SUCLG1 & SUCLG2 or SUCLG1 & SUCLA2
Reaction pageReversibleBalancedEC 6.2.1.5mitochondrial matrix
Human-GEM MAR08663CC BY 4.0Reference data
ADP+MAM02466m+phosphate(3-)ATP+CHEBI:1146900+MAM02465m
Catalysed by SUCLG1 & SUCLG2 or SUCLG1 & SUCLA2
Reaction pageReversibleBalancedEC 6.2.1.5mitochondrial matrix
Human-GEM MAR08667CC BY 4.0Reference data
CHEBI:1146900+GTP+MAM02465mGDP+MAM02466m+phosphate(3-)
Catalysed by SUCLG1 & SUCLG2 or SUCLG1 & SUCLA2
Reaction pageReversibleBalancedEC 6.2.1.5mitochondrial matrix
Human-GEM MAR08668CC BY 4.0Reference data
succinate(2-)+ATP(4-)+coenzyme A(4-)succinyl-CoA+ADP(3-)+hydrogenphosphate
Reaction pageDirection not assertedBalanced
Rhea RHEA:17661CC BY 4.0Reference data
(S)-malate+ATP(4-)+coenzyme A(4-)(S)-malyl-CoA+ADP(3-)+hydrogenphosphate
Reaction pageDirection not assertedBalanced
Rhea RHEA:26193CC BY 4.0Reference data