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Proteins/UNIPROT:P08263
Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis. Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid..
Function from UniProtKB (P08263), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
152 statements
152 statements · 7 reference databases · Subject: GSTA1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
66 reactions
CHEBI:16856+MAM02096c(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 9 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18cytosol
8 names
Resolves to: GSTA1
CHEBI:16856+MAM02096r(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 9 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18endoplasmic reticulum
Human-GEM MAR01053CC BY 4.0Reference data
CHEBI:16856+MAM02096x(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 9 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18peroxisome
Human-GEM MAR01054CC BY 4.0Reference data
12-oxo-leukotriene B4+CHEBI:16856MAM00333c
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or GSTO1 or HPGDS and 8 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18cytosol
Human-GEM MAR01119CC BY 4.0Reference data
12-oxo-leukotriene B4+CHEBI:16856MAM00333m
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 9 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18mitochondrial matrix
Human-GEM MAR01120CC BY 4.0Reference data
12-oxo-leukotriene B4+CHEBI:16856MAM00333r
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 9 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18endoplasmic reticulum
Human-GEM MAR01121CC BY 4.0Reference data
12-oxo-leukotriene B4+CHEBI:16856MAM00333x
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 9 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18peroxisome
Human-GEM MAR01122CC BY 4.0Reference data
CHEBI:16856+prostaglandin J2MAM02864c
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 10 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.188, 2.5.1.18cytosol
Human-GEM MAR01367CC BY 4.0Reference data
CHEBI:16856+prostaglandin A2MAM02863c
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 9 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18cytosol
Human-GEM MAR01370CC BY 4.0Reference data
MAM01662c+CHEBI:16856MAM02860c
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 9 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18cytosol
Human-GEM MAR01379CC BY 4.0Reference data
MAM01234c+CHEBI:16856MAM02859c
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 9 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18cytosol
Human-GEM MAR01384CC BY 4.0Reference data
CHEBI:16856+MAM02776cMAM02862c
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 9 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18cytosol
Human-GEM MAR01398CC BY 4.0Reference data