L-kynurenine

1. Transport of L-Kynurenine

Catalysed by SLC43A1extracellular space, cytosolOne of 3 routes

1. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

Catalysed by KYNU

1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)

Catalysed by KMOcytosol

1. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O

Catalysed by AADAT

1. L-Kynurenine hydrolase

Catalysed by KYNUcytosol

1. L-kynurenine + glyoxylate = kynurenate + glycine + H2O

Catalysed by KYAT3, AADAT

1. 4-methylsulfanyl-2-oxobutanoate + L-kynurenine = kynurenate + L-methionine + H2O

Catalysed by AADAT

1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O

Catalysed by AADAT

1. L-Kynurenine hydrolase

Catalysed by KYNUcytosolOne of 2 routes

1. Transport of L-Kynurenine

Catalysed by SLC7A8extracellular space, cytosolOne of 3 routes

1. L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O

Catalysed by KMO

1. 2-oxopentanoate + L-kynurenine = L-2-aminopentanoate + kynurenate + H2O

Catalysed by AADAT

1. Kynurenine-Oxoglutarate Transaminase

Catalysed by KYAT3, AADATmitochondrial matrixOne of 13 routes

1. 2-oxohexanoate + L-kynurenine = L-2-aminohexanoate + kynurenate + H2O

Catalysed by AADAT

1. N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)

Catalysed by AFMID

1. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O

Catalysed by AADAT

1. an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)

Catalysed by SLC7A11inner side of the membrane, outer side of the membraneOne of 2 routes

1. 2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O

Catalysed by AADAT

1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
2. beta-carboline hydrolysis

Catalysed by AADATcytosol

1. L-Kynurenine hydrolase
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

Catalysed by KYNUcytosol, mitochondrial matrixOne of 32 routes