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Proteins/UNIPROT:P06733
Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis. Also involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production..
[Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor..
Function from UniProtKB (P06733), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
441 statements
441 statements · 9 reference databases · Subject: ENO1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways · Rows fetched: 300
2 reactions
(2R)-2-phosphoglyceratewater+phosphoenolpyruvic acid
Catalysed by ENO1 or ENO3 or ENO2
Reaction pageReversibleBalancedEC 4.2.1.11cytosol
Human-GEM MAR04363CC BY 4.0Reference data
12 names
Resolves to: ENO1
Reaction pageReversibleBalanced
Rhea RHEA:10164CC BY 4.0Reference data