(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

85 compounds within 3 steps: 2 in 1, 18 in 2, 65 in 3

One step

fumaric acidReach from here →
1. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase
Catalysed by ADSLcytosolOne of 2 routes
5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideReach from here →
1. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase
Catalysed by ADSLcytosolOne of 2 routes

Two steps

a quinoneReach from here →
1. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase
2. a quinone + succinate = fumarate + a quinol
Catalysed by ADSL, SDHBcytosol
2',3'-cGAMPReach from here →
1. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase
2. 2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)
Catalysed by ADSL, SLC19A1cytosol, inner side of the membrane, outer side of the membrane
(S)-malate

Three steps

pregnenolone sulfateReach from here →
Catalysed by ADSL, SLC25A10, STScytosol, mitochondrial matrix, Golgi apparatusOne of 2 routes
androsterone 3alpha-sulfateReach from here →

Reach from here →

Catalysed by ADSL, FHcytosolOne of 5 routes

sulfateReach from here →

Catalysed by ADSL, SLC25A10cytosol, mitochondrial matrixOne of 2 routes

ubiquinonesReach from here →

Catalysed by ADSL, SDHD, SDHB, SDHA and 1 morecytosol, mitochondrial matrix

3-fumarylpyruvateReach from here →

Catalysed by ADSL, FAHD1cytosol

sulfiteReach from here →

Catalysed by ADSL, SLC25A10cytosol, mitochondrial matrixOne of 2 routes

4-fumarylacetoacetateReach from here →

Catalysed by ADSL, FAHcytosol

CHEBI:18381Reach from here →

Catalysed by ADSL, ATICcytosol

(6S)-5-methyl-5,6,7,8-tetrahydrofolateReach from here →

Catalysed by ADSL, SLC19A1cytosol, inner side of the membrane, outer side of the membrane

5,6,7,8-tetrahydrofolic acidReach from here →

Catalysed by ADSL, ATICcytosol

thiosulfateReach from here →

Catalysed by ADSL, SLC25A10cytosol, mitochondrial matrixOne of 2 routes

7,8-dihydrofolateReach from here →

Catalysed by ADSL, ATICcytosol

(6S)-5,6,7,8-tetrahydrofolateReach from here →

Catalysed by ADSL, ATICcytosol

2-(N(omega)-L-arginino)succinateReach from here →

Catalysed by ADSL, ASLcytosolOne of 2 routes

N(6)-(1,2-dicarboxyethyl)-AMPReach from here →

Catalysed by ADSL, TNRC6BcytosolOne of 2 routes

5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamideReach from here →

Catalysed by ADSL, ATICcytosolOne of 2 routes

3',3'-cGAMPReach from here →

Catalysed by ADSL, SLC19A1cytosol, inner side of the membrane, outer side of the membrane

Catalysed by ADSL, SLC25A10, STS

cytosol, mitochondrial matrix

One of 3 routes

a 1,4-benzosemiquinoneReach from here →

Catalysed by ADSL, SDHB, CRYZ, TP53I3 and 2 morecytosol

cholesterol sulfateReach from here →

Catalysed by ADSL, SLC25A10, STScytosol, mitochondrial matrix, Golgi apparatusOne of 2 routes

5alpha-dihydrotestosterone sulfateReach from here →

Catalysed by ADSL, SLC25A10, STScytosol, mitochondrial matrixOne of 3 routes

acetoacetateReach from here →

Catalysed by ADSL, FAHcytosolOne of 2 routes

an aryl sulfateReach from here →

Catalysed by ADSL, SLC25A10, ARSL, ARSF and 4 morecytosol, mitochondrial matrix

pyruvateReach from here →

Catalysed by ADSL, FH, ME2, ME3cytosol, mitochondrial matrixOne of 8 routes

(6R)-5,10-methylene-5,6,7,8-tetrahydrofolateReach from here →

Catalysed by ADSL, ATIC, SHMT1, SHMT2cytosolOne of 2 routes

10-formyltetrahydrofolic acidReach from here →

Catalysed by ADSL, ATICcytosolOne of 4 routes

5-methyltetrahydrofolic acidReach from here →

Catalysed by ADSL, ATIC, HNMTcytosol

malonateReach from here →

Catalysed by ADSL, FH, SLC25A10cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

beta-nicotinamide D-ribosideReach from here →

Catalysed by ADSL, SDHB, NQO2cytosol

L-citrullineReach from here →

Catalysed by ADSL, ASL, ASS1cytosol

oxaloacetateReach from here →

Catalysed by ADSL, FHcytosol, mitochondrial matrixOne of 5 routes

L-arginineReach from here →

Catalysed by ADSL, ASLcytosolOne of 2 routes

quinolinic acidReach from here →

Catalysed by ADSL, SLC25A10, SLC22A6cytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

ferrocytochrome cReach from here →

Catalysed by ADSL, SLC25A10, SUOXcytosol, mitochondrial matrix

oxalic acidReach from here →

Catalysed by ADSL, SLC25A10, SLC26A6cytosol, mitochondrial matrix, extracellular space

4-maleylacetoacetateReach from here →

Catalysed by ADSL, FAH, GSTZ1cytosol

CHEBI:17202Reach from here →

Catalysed by ADSL, ATICcytosol

(S)-1-pyrroline-5-carboxylateReach from here →

Catalysed by ADSL, SDHB, PRODH, PRODH2cytosol

enol-oxaloacetateReach from here →

Catalysed by ADSL, FH, SDHB, SDHAcytosolOne of 3 routes

3,3'-diiodo-L-thyronine sulfateReach from here →

Catalysed by ADSL, SLC25A10, STScytosol, mitochondrial matrix, Golgi apparatusOne of 2 routes

ubiquinolReach from here →

Catalysed by ADSL, SDHD, SDHB, SDHA and 3 morecytosol, mitochondrial matrixOne of 6 routes

thiocyanateReach from here →

Catalysed by ADSL, SLC25A10, MPST, TSTcytosol, mitochondrial matrixOne of 2 routes

hydrogen cyanideReach from here →

Catalysed by ADSL, SLC25A10, MPST, TSTcytosol, mitochondrial matrixOne of 2 routes

(6R)-10-formyltetrahydrofolateReach from here →

Catalysed by ADSL, ATIC, MTHFD1, MTHFD1Lcytosol

(6R)-5,10-methylenetetrahydrofolic acidReach from here →

Catalysed by ADSL, ATIC, SHMT1cytosolOne of 5 routes

5'-pGpA(2'-5')Reach from here →

Catalysed by ADSL, SLC19A1, SMPDL3Acytosol, inner side of the membrane, outer side of the membrane