Compound
glutathione disulfide
A glutathione dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized.
Structure
No three-dimensional record for this entry.
- Class
- Organic compound, anion
- Formula
- C20H30N6O12S2
- Mass
- 610.624 g/mol
- Charge
- -2
- InChIKey
- YPZRWBKMTBYPTK-BJDJZHNGSA-L
- SMILES
- [NH3+][C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H]([NH3+])C(=O)[O-])C(=O)NCC(=O)[O-])C(=O)NCC(=O)[O-])C(=O)[O-]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
15 entities
15 entities reached.
0 reported hops15 assembled from the scaffold
- GSRProteinUNIPROT:P00390substrate ofInferred only85 paths17 endpoints
- GPX2ProteinUNIPROT:P18283substrate ofInferred only27 paths27 endpoints
- GPX1ProteinUNIPROT:P07203substrate ofInferred only25 paths25 endpoints
- GSTO1ProteinUNIPROT:P78417metabolized byInferred only22 paths22 endpoints
- GPX4ProteinUNIPROT:P36969substrate ofInferred only20 paths20 endpoints
- PRDX6ProteinUNIPROT:P30041substrate ofInferred only15 paths15 endpoints
- GPX3ProteinUNIPROT:P22352substrate ofInferred only13 paths13 endpoints
- GSTO2ProteinUNIPROT:Q9H4Y5metabolized byInferred only9 paths9 endpoints
- DNAJC10ProteinUNIPROT:Q8IXB1substrate ofInferred only8 paths8 endpoints
- GPX6ProteinUNIPROT:P59796substrate ofInferred only8 paths8 endpoints
- GPX7ProteinUNIPROT:Q96SL4substrate ofInferred only7 paths7 endpoints
- GPX5ProteinUNIPROT:O75715substrate ofInferred only6 paths6 endpoints
Show the remaining 3
- TSTD1ProteinUNIPROT:Q8NFU3substrate ofInferred only5 paths5 endpoints
- GPX8ProteinUNIPROT:Q8TED1substrate ofInferred only4 paths4 endpoints
- glutathioneCompoundCHEBI:57925converted toInferred only3 paths1 endpoint
What the reference databases state
Statements
33 statements
33 statements · 2 reference databases · Subject: glutathione disulfide · Sources: Human-GEM, Rhea
- glutathione disulfide is converted to CHEBI:16856CompoundHuman-GEM MAR04118Inferred only
- glutathione disulfide is converted to CHEBI:16856CompoundHuman-GEM MAR03868Inferred only
- glutathione disulfide is converted to CHEBI:16856CompoundHuman-GEM MAR03869Inferred only
- glutathione disulfide is converted to CHEBI:16856CompoundHuman-GEM MAR03870Inferred only
- CHEBI:16856 is converted to glutathione disulfideCompoundHuman-GEM MAR04116Inferred only
- CHEBI:16856 is converted to glutathione disulfideCompoundHuman-GEM MAR04120Inferred only
- CHEBI:16856 is converted to glutathione disulfideCompoundHuman-GEM MAR04121Inferred only
- glutathione is converted to glutathione disulfideCompoundRhea RHEA:16833Inferred only
- glutathione is converted to glutathione disulfideCompoundRhea RHEA:24112Inferred only
- glutathione is converted to glutathione disulfideCompoundRhea RHEA:75699Inferred only
- glutathione is converted to glutathione disulfideCompoundRhea RHEA:11740Inferred only
- glutathione disulfide is converted to glutathioneCompoundRhea RHEA:11740Inferred only
Show the remaining 21
- glutathione disulfide is converted to glutathioneCompoundRhea RHEA:24112Inferred only
- glutathione disulfide is converted to glutathioneCompoundRhea RHEA:75699Inferred only
- glutathione disulfide is metabolised by GSTO1ProteinRhea RHEA:15969Inferred only
- glutathione disulfide is metabolised by GSTO2ProteinRhea RHEA:15969Inferred only
- glutathione disulfide is a substrate of DNAJC10ProteinRhea RHEA:21064Inferred only
- glutathione disulfide is a substrate of GPX1ProteinHuman-GEM MAR00988Inferred only
- glutathione disulfide is a substrate of GPX2ProteinHuman-GEM MAR00988Inferred only
- glutathione disulfide is a substrate of GPX3ProteinHuman-GEM MAR00988Inferred only
- glutathione disulfide is a substrate of GPX4ProteinHuman-GEM MAR00988Inferred only
- glutathione disulfide is a substrate of GPX5ProteinHuman-GEM MAR00988Inferred only
- glutathione disulfide is a substrate of GPX6ProteinHuman-GEM MAR00988Inferred only
- glutathione disulfide is a substrate of GPX7ProteinHuman-GEM MAR00988Inferred only
- glutathione disulfide is a substrate of GPX8ProteinHuman-GEM MAR00988Inferred only
- glutathione disulfide is a substrate of GSRProteinHuman-GEM MAR03868Inferred only
- glutathione disulfide is a substrate of GSRProteinHuman-GEM MAR03869Inferred only
- glutathione disulfide is a substrate of GSRProteinHuman-GEM MAR03870Inferred only
- glutathione disulfide is a substrate of GSRProteinHuman-GEM MAR04118Inferred only
- glutathione disulfide is a substrate of GSRProteinRhea RHEA:11740Inferred only
- glutathione disulfide is a substrate of PRDX6ProteinHuman-GEM MAR00988Inferred only
- glutathione disulfide is a substrate of TSTD1ProteinRhea RHEA:14505Inferred only
- glutathione disulfide is a substrate of TXNDC12ProteinRhea RHEA:21064Inferred only
Reactions
59 reactions
5(S)-HPETE+2CHEBI:168565(S)-HETE+glutathione disulfide+water
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageLeft to rightBalancedEC 1.11.1.9cytosol
Human-GEM MAR00960CC BY 4.0Reference data
5(S)-HPETE+2CHEBI:168565(S)-HETE+glutathione disulfide+water
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageLeft to rightBalancedEC 1.11.1.9mitochondrial matrix
Human-GEM MAR00963CC BY 4.0Reference data
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate+glutathione disulfide+water15(S)-HPETE+2CHEBI:16856
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageReversibleBalancedEC 1.11.1.9cytosol
Human-GEM MAR00988CC BY 4.0Reference data
12(S)-HPETE+2CHEBI:16856MAM00307c+glutathione disulfide+water
Catalysed by ALOX12
Reaction pageLeft to rightBalancedEC 1.13.11.31cytosol
Human-GEM MAR01037CC BY 4.0Reference data
12(S)-HPETE+2CHEBI:16856MAM00307r+glutathione disulfide+water
Catalysed by ALOX12
Reaction pageLeft to rightBalancedEC 1.13.11.31endoplasmic reticulum
Human-GEM MAR01039CC BY 4.0Reference data
(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate+2CHEBI:16856MAM01202c+glutathione disulfide+water
Catalysed by ALOX12
Reaction pageLeft to rightBalancedEC 1.13.11.31cytosol
Human-GEM MAR01063CC BY 4.0Reference data
glutathione disulfide+proton+NADH(2-)2CHEBI:16856+NAD(+)
Catalysed by GSR
Reaction pageLeft to rightBalancedEC 1.8.1.7cytosol
Human-GEM MAR03868CC BY 4.0Reference data
glutathione disulfide+proton+NADH(2-)2CHEBI:16856+NAD(+)
Catalysed by GSR
Reaction pageLeft to rightBalancedEC 1.8.1.7mitochondrial matrix
Human-GEM MAR03869CC BY 4.0Reference data
glutathione disulfide+proton+NADPH(4-)2CHEBI:16856+NADP(3-)
Catalysed by GSR
Reaction pageLeft to rightBalancedEC 1.8.1.7mitochondrial matrix
Human-GEM MAR03870CC BY 4.0Reference data
2CHEBI:16856+hydrogen peroxideglutathione disulfide+2water
Catalysed by GPX7 or PRDX1 or PRDX6 or PRDX5 or GPX8 or PRDX3 or GPX4 or PRDX2 or GPX2 or GPX6 or GPX3 or GPX5 and 1 more alternative
Reaction pageLeft to rightBalancedEC 1.11.1.9, 1.11.1.24, 1.11.1.25, 1.11.1.26, 1.11.1.27, 1.11.1.28, 1.11.1.29cytosol
Human-GEM MAR04116CC BY 4.0Reference data
glutathione disulfide+proton+NADPH(4-)2CHEBI:16856+NADP(3-)
Catalysed by GSR
Reaction pageLeft to rightBalancedEC 1.8.1.7cytosol
Human-GEM MAR04118CC BY 4.0Reference data
2CHEBI:16856+hydrogen peroxideglutathione disulfide+2water
Catalysed by GPX7 or PRDX1 or PRDX6 or PRDX5 or GPX8 or GPX4 or PRDX2 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageLeft to rightBalancedEC 1.11.1.9, 1.11.1.24, 1.11.1.25, 1.11.1.26, 1.11.1.27, 1.11.1.28, 1.11.1.29extracellular space
Human-GEM MAR04120CC BY 4.0Reference data
Other names
2 names
Resolves to: glutathione disulfide
- Also called
- glutathione disulfide dianion
- Systematic name
- (2S,2'S)-5,5'-[disulfanediylbis({(2R)-3-[(carboxylatomethyl)amino]-3-oxopropane-1,2-diyl}imino)]bis(2-azaniumyl-5-oxopentanoate)