L-tryptophan

1. beta-carboline hydrolysis

No catalyst recordedcytosol

1. L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)

Catalysed by TPH1, TPH2cytosol

1. transport of leucine and tryptophan (cytosol to extracellular)

Catalysed by SLC7A5extracellular space, cytosolOne of 4 routes

1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

Catalysed by TPH1, TPH2

1. transport of homoserine and tryptophan (cytosol to extracellular)

Catalysed by SLC7A5extracellular space, cytosolOne of 3 routes

1. transport of histidine and tryptophan (cytosol to extracellular)

Catalysed by SLC7A6extracellular space, cytosolOne of 2 routes

1. transport of citrulline and tryptophan (cytosol to extracellular)

Catalysed by SLC7A9, SLC3A1, SLC7A6extracellular space, cytosol

1. transport of tryptophan and valine (cytosol to extracellular)

Catalysed by SLC7A5extracellular space, cytosolOne of 4 routes

1. transport of arginine and tryptophan (cytosol to extracellular)

Catalysed by SLC7A6extracellular space, cytosolOne of 2 routes

1. PROTEIN_BS

No catalyst recordedcytosol

1. L-tryptophan decarboxy-lyase

Catalysed by DDCcytosol

1. transport of threonine and tryptophan (cytosol to extracellular)

Catalysed by SLC7A5extracellular space, cytosolOne of 4 routes

1. transport of isoleucine and tryptophan (cytosol to extracellular)

Catalysed by SLC7A5extracellular space, cytosolOne of 4 routes

1. transport of proline and tryptophan (cytosol to extracellular)

Catalysed by ABCA1, SLC7A5extracellular space, cytosolOne of 4 routes

1. Transport of 3-Hydroxy-L-Kynurenine

Catalysed by SLC7A5extracellular space, cytosolOne of 2 routes

1. transport of cysteine and tryptophan (cytosol to extracellular)

Catalysed by SLC7A5extracellular space, cytosolOne of 4 routes

1. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

Catalysed by IL4I1One of 2 routes

1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

Catalysed by TPH1, TPH2

1. transport of tryptophan and tyrosine (cytosol to extracellular)

Catalysed by SLC7A5extracellular space, cytosolOne of 4 routes

1. transport of lysine and tryptophan (cytosol to extracellular)

Catalysed by SLC7A6extracellular space, cytosolOne of 2 routes

1. transport of glutamine and tryptophan (cytosol to extracellular)

Catalysed by SLC7A5extracellular space, cytosolOne of 4 routes

1. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

Catalysed by TPH1, TPH2cytosolOne of 2 routes

1. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

Catalysed by WARS1cytosol

1. Transport of L-Tryptophan by Atb0 Transporter

Catalysed by SLC6A14extracellular space, cytosolOne of 2 routes

1. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)

Catalysed by SLC7A13inner side of the membrane, outer side of the membraneOne of 2 routes

1. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

Catalysed by IDO1, TDO2, IDO2cytosol

1. transport of ornithine and tryptophan (cytosol to extracellular)

Catalysed by SLC7A6extracellular space, cytosolOne of 2 routes

1. transport of glycine and tryptophan (cytosol to extracellular)

Catalysed by SLC7A5extracellular space, cytosolOne of 5 routes

1. transport of methionine and tryptophan (cytosol to extracellular)

Catalysed by SLC7A5extracellular space, cytosolOne of 4 routes

1. transport of alanine and tryptophan (cytosol to extracellular)

Catalysed by SLC7A5extracellular space, cytosolOne of 4 routes

1. transport of asparagine and tryptophan (cytosol to extracellular)

Catalysed by SLC7A5extracellular space, cytosolOne of 3 routes

1. transport of phenylalanine and tryptophan (cytosol to extracellular)

Catalysed by SLC7A5extracellular space, cytosolOne of 6 routes

1. L-tryptophan + O2 = N-formyl-L-kynurenine

Catalysed by IDO1, TDO2, IDO2

1. Transport of L-Tryptophan by Atb0 Transporter
2. Carnitine Transport by Atb0

Catalysed by SLC6A14extracellular space, cytosol

1. transport of glycine and tryptophan (cytosol to extracellular)
2. bile acid-CoA: amino acid N-acyltransferase

Catalysed by SLC7A5, BAATextracellular space, cytosol, peroxisomeOne of 40 routes