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Proteins/UNIPROT:Q6NUM6
Involved in the biosynthesis of wybutosine, a hyper modified guanosine with a tricyclic base located at position 37 of eukaryotic phenylalanine tRNA (tRNA(Phe)) that contributes to maintenance of the translational reading frame (By similarity). Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity)..
Function from UniProtKB (Q6NUM6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
26 statements
26 statements · 3 reference databases · Subject: TYW1B · Sources: Human Protein Atlas, Rhea, UniProt
1 reaction
CHEBI:73542+pyruvate+S-adenosyl-L-methionineCHEBI:64315+5'-deoxyadenosine+L-methionine+carbon dioxide+water
Reaction pageLeft to rightBalanced
Rhea RHEA:36347CC BY 4.0Reference data
3 names
Resolves to: TYW1B