Compound
(R)-methylmalonyl-CoA
Pentaanion of (R)-methylmalonyl-CoA arising from deprotonation of phosphate, diphosphate and carboxylic acid functions.
Definition from ChEBI (CHEBI:57326), read 2026-09-23. CC BY 4.0.
Structure
No three-dimensional record for this entry.
- Class
- Organic compound, anion
- Formula
- C25H35N7O19P3S
- Mass
- 862.574 g/mol
- Charge
- -5
- InChIKey
- MZFOKIKEPGUZEN-AGCMQPJKSA-I
- SMILES
- C[C@H](C(=O)[O-])C(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
1 entity
1 entities reached.
0 reported hops1 assembled from the scaffold
What the reference databases state
Statements
8 statements
8 statements · 2 reference databases · Subject: (R)-methylmalonyl-CoA · Sources: Human-GEM, Rhea
- (S)-methylmalonyl-CoA is converted to (R)-methylmalonyl-CoACompoundHuman-GEM MAR03213Inferred only
- (S)-methylmalonyl-CoA is converted to (R)-methylmalonyl-CoACompoundRhea RHEA:20553Inferred only
- (R)-methylmalonyl-CoA is converted to CHEBI:15380CompoundHuman-GEM MAR03215Inferred only
- propanoyl-CoA is converted to (R)-methylmalonyl-CoACompoundRhea RHEA:27666Inferred only
- (R)-methylmalonyl-CoA is converted to propanoyl-CoACompoundRhea RHEA:27666Inferred only
- (R)-methylmalonyl-CoA is converted to succinyl-CoACompoundRhea RHEA:22888Inferred only
- (R)-methylmalonyl-CoA is a substrate of MMUTProteinRhea RHEA:22888Inferred only
- (R)-methylmalonyl-CoA is a substrate of MMUTProteinHuman-GEM MAR03215Inferred only
Reactions
9 reactions
(S)-methylmalonyl-CoA(R)-methylmalonyl-CoA
Catalysed by MCEE
Reaction pageLeft to rightBalancedEC 5.1.99.1mitochondrial matrix
Human-GEM MAR03213CC BY 4.0Reference data
(R)-methylmalonyl-CoACHEBI:15380
Catalysed by MMUT
Reaction pageLeft to rightBalancedEC 5.4.99.2mitochondrial matrix
Human-GEM MAR03215CC BY 4.0Reference data
2-methyl-3-oxopropanoic acid+CHEBI:1146900+NAD(+)(R)-methylmalonyl-CoA+proton+NADH(2-)
Catalysed by ALDH6A1
Reaction pageLeft to rightBalancedEC 1.2.1.18mitochondrial matrix
Human-GEM MAR03761CC BY 4.0Reference data
CHEBI:1146900+proton+MAM02479m(R)-methylmalonyl-CoA+water
Catalysed by ALDH6A1
Reaction pageLeft to rightBalancedEC 3.1.2.17, 1.2.1.18mitochondrial matrix
Human-GEM MAR03763CC BY 4.0Reference data
a long-chain fatty acyl-[mycocerosate synthase]+4(R)-methylmalonyl-CoA+8NADPH(4-)+12hydrontetramethylated-mycocerosoyl-[mycocerosate synthase]+4carbon dioxide+8NADP(3-)+4coenzyme A(4-)+4water
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:10588CC BY 4.0Reference data
(R)-methylmalonyl-CoA(S)-methylmalonyl-CoA
Catalysed by MCEE
Reaction pageRight to leftBalanced
Rhea RHEA:20553CC BY 4.0Reference data
(R)-methylmalonyl-CoAsuccinyl-CoA
Catalysed by MMUT
Reaction pageLeft to rightBalanced
Rhea RHEA:22888CC BY 4.0Reference data
(R)-methylmalonyl-CoA+hydronpropanoyl-CoA+carbon dioxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:27666CC BY 4.0Reference data
a long-chain fatty acyl-[mycocerosate synthase]+3(R)-methylmalonyl-CoA+6NADPH(4-)+9hydrontrimethylated-mycocerosoyl-[mycocerosate synthase]+3carbon dioxide+6NADP(3-)+3coenzyme A(4-)+3water
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:50352CC BY 4.0Reference data