PCK2

Mitochondrial phosphoenolpyruvate carboxykinase that catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Can play an active role in glyceroneogenesis and gluconeogenesis. In lipogenic cells such as adipocytes, it generates PEP via the mitochondrial pyruvate-to-PEP bypass, driving the PEP flux required for cytosolic glycerol 3-phosphate and triglyceride synthesis (By similarity). Also acts as a serine/threonine-protein kinase: phosphorylates and activates ACSL4, thereby promoting ferroptosis..

Function from UniProtKB (Q16822), read 2026-09-23. CC BY 4.0.