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Proteins/UNIPROT:Q9BXD5
Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (Probable)..
Function from UniProtKB (Q9BXD5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
29 statements
29 statements · 6 reference databases · Subject: NPL · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea
2 reactions
aldehydo-N-acetyl-D-mannosamine+pyruvateN-acetyl-beta-neuraminic acid
Catalysed by NPL
Reaction pageReversibleBalancedEC 4.1.3.3cytosol
Human-GEM MAR08373CC BY 4.0Reference data
aceneuramatealdehydo-N-acetyl-D-mannosamine+pyruvate
Catalysed by NPL
Reaction pageDirection not assertedBalanced
Rhea RHEA:23296CC BY 4.0Reference data
8 names
Resolves to: NPL