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Proteins/UNIPROT:P02730
Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine..
(Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes. Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes..
Function from UniProtKB (P02730), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
7 rows
46 statements
46 statements · 6 reference databases · Subject: SLC4A1 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea
3 reactions
chlorine(.)+hydrogencarbonatechlorine(.)+hydrogencarbonate
Transported by SLC4A1 or SLC26A4 or SLC26A3 or SLC4A9 or SLC4A3 or SLC4A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06525CC BY 4.0Reference data
(5-hydroxyindol-3-yl)acetate+sulfate(5-hydroxyindol-3-yl)acetate
8 names
Resolves to: SLC4A1
Transported by SLC4A1
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR09059CC BY 4.0Reference data
hydrogencarbonate+chloridehydrogencarbonate+chloride
Transported by SLC26A4 or SLC4A1 or SLC4A2 or SLC4A3 or SLC26A9 or SLC26A11 or SLC26A7
Reaction pageDirection not assertedBalanced
Rhea RHEA:72363CC BY 4.0Reference data