(S)-malyl-CoA

1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate

Catalysed by SUCLG1, SUCLA2One of 2 routes

1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. (S)-malate:NAD+ oxidoreductase (decarboxylating)

Catalysed by SUCLG1, SUCLA2, ME2, ME3mitochondrial matrixOne of 5 routes

1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)

Catalysed by SUCLG1, SUCLA2, SLC25A10inner side of the membrane, outer side of the membraneOne of 2 routes

1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. transport of malate and sulfate (cytosol to mitochondria)

Catalysed by SUCLG1, SUCLA2, SLC25A10mitochondrial matrix, cytosolOne of 4 routes

1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. transport of malate and OAA (cytosol to mitochondria)

Catalysed by SUCLG1, SUCLA2mitochondrial matrix, cytosolOne of 5 routes

1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. transport of malate and sulfite (cytosol to mitochondria)

Catalysed by SUCLG1, SUCLA2, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. (S)-malate + a quinone = enol-oxaloacetate + a quinol

Catalysed by SUCLG1, SUCLA2, SDHB, SDHA

1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. (S)-malate hydro-lyase (fumarate-forming)

Catalysed by SUCLG1, SUCLA2, FHcytosolOne of 5 routes

1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. (S)-malate + a quinone = enol-oxaloacetate + a quinol

Catalysed by SUCLG1, SUCLA2, SDHB, SDHA

1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. Citrate Transport, Mitochondrial

Catalysed by SUCLG1, SUCLA2, SLC25A1mitochondrial matrix, cytosolOne of 5 routes

1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

Catalysed by SUCLG1, SUCLA2, SLC25A1mitochondrial matrix, cytosolOne of 3 routes

1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

Catalysed by SUCLG1, SUCLA2, SLC25A1mitochondrial matrix, cytosolOne of 3 routes

1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. transport of malate and thiosulfate (cytosol to mitochondria)

Catalysed by SUCLG1, SUCLA2, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

Catalysed by SUCLG1, SUCLA2, CLYBL

1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. transport of malate and OAA (cytosol to mitochondria)
3. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)

Catalysed by SUCLG1, SUCLA2, CSmitochondrial matrix, cytosolOne of 2 routes

1. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
3. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)

Catalysed by and 6 more