glutathione

One step

• 2-phenylpropan-2-olReach from here →
  1. cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O

  Catalysed by CLIC2, GPX1, GPX2, GPX4

• a hydroxy polyunsaturated fatty acidReach from here →
  1. a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O

  Catalysed by GPX1, GPX2, GPX4

• tauroursodeoxycholateReach from here →
  1. tauroursodeoxycholate(in) + glutathione(in) + ATP + H2O = tauroursodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by ABCC4inner side of the membrane, outer side of the membrane

• glycoursodeoxycholateReach from here →
  1. glycoursodeoxycholate(in) + glutathione(in) + ATP + H2O = glycoursodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by ABCC4inner side of the membrane, outer side of the membrane

• (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by GPX1, GPX4

• (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →
  1. 11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate

  Catalysed by GSTP1, GSTM1, GSTM2

• prostaglandin A2-S-(R)-glutathioneReach from here →
  1. prostaglandin A2 + glutathione = prostaglandin A2-S-(R)-glutathione

  Catalysed by GSTA1, GSTM1

• prostaglandin A2-S-(S)-glutathioneReach from here →
  1. prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione

  Catalysed by GSTP1, GSTM1

• prostaglandin J2-S-(R)-glutathioneReach from here →
  1. prostaglandin J2 + glutathione = prostaglandin J2-S-(R)-glutathione

  Catalysed by GSTA1, GSTP1, GSTM1

• prostaglandin J2-S-(S)-glutathioneReach from here →
  1. prostaglandin J2 + glutathione = prostaglandin J2-S-(S)-glutathione

  Catalysed by GSTP1, GSTM1

• 2,4-dinitrophenyl-S-glutathioneReach from here →
  1. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)

  Catalysed by PTGES, LANCL1, GSTM4, MGST2

• (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →
  1. (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate

  Catalysed by GSTM4, LTC4S

• S-methyl glutathioneReach from here →
  1. apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

  Catalysed by MMACHC

• S-adenosylglutathioneReach from here →
  1. apo-[alkylcobalamin reductase] + adenosylcob(III)alamin + glutathione = S-adenosylglutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

  Catalysed by MMACHC

• a halide anionReach from here →
  1. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by GSTT4, GSTA4, GSTZ1, LANCL1 and 19 more

• sulfiteReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by TSTD1One of 2 routes

• urateReach from here →
  1. urate(out) + glutathione(in) = urate(in) + glutathione(out)

  Catalysed by SLC22A13inner side of the membrane, outer side of the membrane

• methylarsonous acidReach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by GSTO1, GSTO2

• arsenic triglutathioneReach from here →
  1. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by AS3MTOne of 3 routes

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by MGST3

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by GPX1, GPX4

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by GPX1, GPX4

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by GPX1, GPX4

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by GPX1, GPX4

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by GPX4

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by GSTP1

• a quinolReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by SQOR

• L-ascorbic acidReach from here →
  1. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by CLIC1, GSTO1, GSTO2

• glycocholateReach from here →
  1. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by ABCC4inner side of the membrane, outer side of the membrane

• cholateReach from here →
  1. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by ABCC4inner side of the membrane, outer side of the membrane

• hydrogen sulfideReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by TSTD1

• an alcoholReach from here →
  1. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by CP, PRDX6

• glycochenodeoxycholateReach from here →
  1. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by ABCC4inner side of the membrane, outer side of the membrane

• taurocholateReach from here →
  1. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by ABCC4inner side of the membrane, outer side of the membrane

• tert-butanolReach from here →
  1. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by CLIC2, GPX1, GPX2, GPX3 and 1 more

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by GPX1, GPX2, GPX4

• (R)-S-lactoylglutathioneReach from here →
  1. (R)-S-lactoylglutathione = methylglyoxal + glutathione

  Catalysed by GLO1

• S-formylglutathioneReach from here →
  1. S-formylglutathione + H2O = formate + glutathione + H(+)

  Catalysed by ESD

• leukotriene C4Reach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione

  Catalysed by MGST3, GSTM4, LTC4S, MGST2

• glutathione disulfideReach from here →
  1. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)

  Catalysed by GSROne of 22 routes

• 5-oxo-L-prolineReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline

  Catalysed by CHAC2, CHAC1

• S-sulfanylglutathioneReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)

  Catalysed by ETHE1One of 4 routes

• L-cysteinylglycineReach from here →
  1. glutathione + H2O = L-cysteinylglycine + L-glutamate

  Catalysed by GGT3P, GGT1, GGT5, GGT6 and 1 moreOne of 2 routes

• ubiquinol-10Reach from here →
  1. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10

  Catalysed by SQOR

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by GPX1, GPX4

• glycodeoxycholateReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by ABCC4inner side of the membrane, outer side of the membrane

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by GPX1, GPX2, GPX4

• (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by PTGES, MGST3, GPX1, GPX2 and 2 more

• (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by GPX1, GPX4

• an S-substituted glutathioneReach from here →
  1. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by GSTT4, GSTA4, GSTZ1, LANCL1 and 19 moreOne of 2 routes