N(8)-acetylspermidine

1. N(8)-acetylspermidine + H2O = spermidine + acetate

Catalysed by HDAC10

1. N8-acetylspermidine to spermidine conversion

No catalyst recordedcytosolOne of 2 routes

1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)

Catalysed by SAT1, SAT2cytosolOne of 3 routes

1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. transport of 2-hydroxybutyrate and acetate (cytosol to extracellular)

Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A7 and 1 moreextracellular space, cytosolOne of 2 routes

1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. transport of acetate and acetoacetate (cytosol to extracellular)
3. (S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate

Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A6 and 3 moreextracellular space, cytosol

1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. Carnitine O-Palmitoyltransferase