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Proteins/UNIPROT:O15427
Proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate. Plays a predominant role in L-lactate efflux from highly glycolytic cells (By similarity)..
Function from UniProtKB (O15427), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
270 statements
270 statements · 6 reference databases · Subject: SLC16A3 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
31 reactions
(R)-lactic acid+proton(R)-lactic acid+proton
Transported by SLC16A8 or SLC16A6 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR03858CC BY 4.0Reference data
4 names
Resolves to: SLC16A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04928CC BY 4.0Reference data
proton+pyruvateproton+pyruvate
Transported by SLC16A8 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, peroxisome
Human-GEM MAR04930CC BY 4.0Reference data
Transported by SLC16A8 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04935CC BY 4.0Reference data
(R)-3-hydroxybutyric acid+proton(R)-3-hydroxybutyric acid+proton
Transported by SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05018CC BY 4.0Reference data
2-oxobutanoate+proton2-oxobutanoate+proton
Transported by SLC16A8 or SLC16A6 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR05348CC BY 4.0Reference data
2-oxobutanoate+proton2-oxobutanoate+proton
Transported by SLC16A8 or SLC16A6 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedmitochondrial matrix, mitochondrial intermembrane space, cytosol
Human-GEM MAR05349CC BY 4.0Reference data
proton+(S)-lactic acidproton+(S)-lactic acid
Transported by SLC16A8 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR05998CC BY 4.0Reference data
acetoacetate+pyruvateacetoacetate+pyruvate
Transported by SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06000CC BY 4.0Reference data
2-hydroxybutyric acid+pyruvate2-hydroxybutyric acid+pyruvate
Transported by SLC16A8 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06007CC BY 4.0Reference data
2-hydroxybutyric acid+(S)-lactic acid2-hydroxybutyric acid+(S)-lactic acid
Transported by SLC16A8 or SLC16A6 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06011CC BY 4.0Reference data
2-oxoglutarate(2-)+pyruvate2-oxoglutarate(2-)+pyruvate
Transported by SLC16A8 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06014CC BY 4.0Reference data