acetoacetyl-CoA

1. acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+)

Catalysed by ACOT8

1. acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)

Catalysed by HMGCS2, HMGCS1

1. (3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + NADH + H(+)

Catalysed by HADH, HSD17B10

1. acetoacetyl-CoA + (R)-carnitine = O-3-oxobutanoyl-(R)-carnitine + CoA

Catalysed by CRAT

1. acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+)
2. (S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate

Catalysed by ACOT8, ADHFE1

1. acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+)
2. transport of 2-hydroxybutyrate and acetoacetate (cytosol to extracellular)

Catalysed by ACOT8, SLC16A4, SLC16A5, SLC16A7 and 1 moreextracellular space, cytosolOne of 2 routes

1. acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)
2. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate
3. Production of Glutaryl Carnitine

Catalysed by HMGCS2, HMGCS1, SUGCT, CPT1A and 2 morecytosolOne of 4 routes

1. acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+)
2. transport of acetoacetate and L-lactate (cytosol to extracellular)
3. Transport of Prostaglandin E3, Lactate Antiport