2-(N(omega)-L-arginino)succinate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

402 compounds within 3 steps: 4 in 1, 61 in 2, 337 in 3

One step

L-citrullineReach from here →
1. L-citrulline + L-aspartate + ATP = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)
Catalysed by ASS1
L-arginineReach from here →
1. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)
Catalysed by ASLcytosolOne of 2 routes
fumaric acidReach from here →
1. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)
Catalysed by ASLcytosolOne of 2 routes
L-aspartateReach from here →
1. L-citrulline + L-aspartate + ATP = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)
Catalysed by ASS1

Two steps

CHEBI:1146900Reach from here →
1. L-citrulline + L-aspartate + ATP = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)
2. acetyl-CoA:L-aspartate N-acetyltransferase
Catalysed by ASS1, NAT8Lmitochondrial matrix
N(omega)-methyl-L-arginineReach from here →
1. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)
2. N(omega)-methyl-L-arginine(in) + L-arginine(out) = N(omega)-methyl-L-arginine(out) + L-arginine(in)
Catalysed by ASL, SLC25A29cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes
a quinone

Reach from here →

Catalysed by ASL, SDHBcytosol

L-homoarginineReach from here →

Catalysed by ASL, SLC25A29cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

(S)-malateReach from here →

Catalysed by ASL, FHcytosolOne of 5 routes

L-leucineReach from here →

Catalysed by ASL, SLC3A2, SLC7A6, SLC7A7cytosol, extracellular spaceOne of 10 routes

CHEBI:15699Reach from here →

Catalysed by ASL, SLC7A6cytosol, extracellular spaceOne of 3 routes

N-carbamoyl-L-aspartic acidReach from here →

Catalysed by ASS1, CADcytosol

CHEBI:15971Reach from here →

Catalysed by ASL, SLC7A5, SLC7A6cytosol, extracellular spaceOne of 10 routes

sulfateReach from here →

Catalysed by ASL, SLC25A10cytosol, mitochondrial matrixOne of 4 routes

ureaReach from here →

Catalysed by ASL, ARG1cytosolOne of 3 routes

L-cystineReach from here →

Catalysed by ASL, SLC7A9cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

ubiquinonesReach from here →

Catalysed by ASL, SDHD, SDHB, SDHA and 1 morecytosol, mitochondrial matrix

L-valineReach from here →

Catalysed by ASL, SLC7A6cytosol, extracellular spaceOne of 5 routes

oxaloacetateReach from here →

Catalysed by ASS1, GOT2mitochondrial matrixOne of 5 routes

nitric oxideReach from here →

Catalysed by ASL, NOS3, NOS1, NOS2cytosolOne of 2 routes

protein polypeptide chainReach from here →

Catalysed by ASLcytosolOne of 2 routes

3-fumarylpyruvateReach from here →

Catalysed by ASL, FAHD1cytosol

CHEBI:16857Reach from here →

Catalysed by ASL, SLC7A6cytosol, extracellular spaceOne of 4 routes

N-acetyl-L-aspartateReach from here →

Catalysed by ASS1, NAT8Lmitochondrial matrixOne of 2 routes

L-isoleucineReach from here →

Catalysed by ASL, SLC7A6cytosol, extracellular spaceOne of 4 routes

CHEBI:17203Reach from here →

Catalysed by ASL, SLC7A6cytosol, extracellular spaceOne of 5 routes

sulfiteReach from here →

Catalysed by ASL, SLC25A10cytosol, mitochondrial matrixOne of 2 routes

agmatineReach from here →

Catalysed by ASLcytosol, mitochondrial matrix

L-cysteineReach from here →

Catalysed by ASL, SLC7A6cytosol, extracellular spaceOne of 7 routes

CHEBI:17895Reach from here →

Catalysed by ASL, SLC7A6cytosol, extracellular spaceOne of 4 routes

CHEBI:17927Reach from here →

Catalysed by ASL, SLC3A2, SLC7A6cytosol, extracellular space

CHEBI:18019Reach from here →

Catalysed by ASL, SLC3A2, SLC7A5, SLC7A6cytosol, extracellular spaceOne of 8 routes

4-fumarylacetoacetateReach from here →

Catalysed by ASL, FAHcytosol

L-glutamineReach from here →

Catalysed by ASL, SLC7A6cytosol, extracellular spaceOne of 9 routes

potassium atomReach from here →

Catalysed by ASS1, SLC1A7, SLC1A3, SLC1A2 and 2 moreextracellular space, cytosol

K(+)Reach from here →

Catalysed by ASS1, SLC1A7, SLC1A3, SLC1A2 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

Asp-tRNA(Asp)Reach from here →

Catalysed by ASS1, DARS1cytosol

isocyanateReach from here →

Catalysed by ASS1, LACC1

chlorine(.)Reach from here →

Catalysed by ASL, SLC6A14cytosol, extracellular spaceOne of 2 routes

L-lysineReach from here →

Catalysed by ASL, SLC7A9, SLC25A29, SLC7A6cytosol, inner side of the membrane, outer side of the membrane

putrescineReach from here →

Catalysed by ASL, SLC3A2, SLC7A7cytosol, extracellular space

N-carbamoyl-L-aspartateReach from here →

Catalysed by ASS1, CAD

thiosulfateReach from here →

Catalysed by ASL, SLC25A10cytosol, mitochondrial matrixOne of 2 routes

L-ornithineReach from here →

Catalysed by ASL, ARG1cytosolOne of 25 routes

glycineReach from here →

Catalysed by ASL, SLC7A6cytosol, extracellular spaceOne of 3 routes

4-guanidinobutanoateReach from here →

Catalysed by ASL, GATMcytosol

N(6)-(1,2-dicarboxyethyl)-AMPReach from here →

Catalysed by ASL, ADSL, TNRC6BcytosolOne of 4 routes

3-guanidinopropanoateReach from here →

Catalysed by ASL, GATMcytosol

L-histidineReach from here →

Catalysed by ASL, SLC7A6cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

guanidinoacetateReach from here →

Catalysed by ASL, GATMcytosolOne of 2 routes