Compound
(5-hydroxyindol-3-yl)acetaldehyde
An aldehyde that is acetaldehyde substituted by a 5-hydroxyindol-3-yl group.
Definition from ChEBI (CHEBI:50157), read 2026-09-23. CC BY 4.0.
Structure
No depiction stored
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- Class
- Organic compound
- Formula
- C10H9NO2
- Mass
- 175.187 g/mol
- Charge
- 0
- InChIKey
- OBFAPCIUSYHFIE-UHFFFAOYSA-N
- SMILES
- O=CCc1cnc2ccc(O)cc12
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
14 entities
14 entities reached.
0 reported hops14 assembled from the scaffold
- ALDH2ProteinUNIPROT:P05091metabolized byInferred only64 paths32 endpoints
- MAOAProteinUNIPROT:P21397metabolized byInferred only36 paths36 endpoints
- ALDH1B1ProteinUNIPROT:P30837metabolized byInferred only22 paths11 endpoints
- ADH1AProteinUNIPROT:P07327metabolized byInferred only17 paths17 endpoints
- ADH4ProteinUNIPROT:P08319metabolized byInferred only14 paths14 endpoints
- ALDH9A1ProteinUNIPROT:P49189metabolized byInferred only14 paths7 endpoints
- ALDH3A2ProteinUNIPROT:P51648metabolized byInferred only14 paths14 endpoints
- AOX1ProteinUNIPROT:Q06278metabolized byInferred only14 paths14 endpoints
- ALDH7A1ProteinUNIPROT:P49419metabolized byInferred only13 paths13 endpoints
- ADH7ProteinUNIPROT:P40394metabolized byInferred only12 paths12 endpoints
- ADH1CProteinUNIPROT:P00326metabolized byInferred only11 paths11 endpoints
- ADH1BProteinUNIPROT:P00325metabolized byInferred only10 paths10 endpoints
What the reference databases state
Statements
27 statements
27 statements · 2 reference databases · Subject: (5-hydroxyindol-3-yl)acetaldehyde · Sources: Human-GEM, Rhea
- (5-hydroxyindol-3-yl)acetaldehyde is converted to (5-hydroxyindol-3-yl)acetateCompoundHuman-GEM MAR00051Inferred only
- (5-hydroxyindol-3-yl)acetate is converted to (5-hydroxyindol-3-yl)acetaldehydeCompoundRhea RHEA:31215Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is converted to (5-hydroxyindol-3-yl)acetateCompoundHuman-GEM MAR04560Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is converted to (5-hydroxyindol-3-yl)acetateCompoundRhea RHEA:31215Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is converted to (5-hydroxyindol-3-yl)acetateCompoundHuman-GEM MAR04559Inferred only
- serotonin is converted to (5-hydroxyindol-3-yl)acetaldehydeCompoundHuman-GEM MAR04558Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is converted to serotoninCompoundRhea RHEA:69072Inferred only
- serotonin is converted to (5-hydroxyindol-3-yl)acetaldehydeCompoundRhea RHEA:69072Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is metabolised by ADH1AProteinHuman-GEM MAR04561Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is metabolised by ADH1BProteinHuman-GEM MAR04561Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is metabolised by ADH1CProteinHuman-GEM MAR04561Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is metabolised by ADH4ProteinHuman-GEM MAR04561Inferred only
Show the remaining 15
- (5-hydroxyindol-3-yl)acetaldehyde is metabolised by ADH5ProteinHuman-GEM MAR04561Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is metabolised by ADH6ProteinHuman-GEM MAR04561Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is metabolised by ADH7ProteinHuman-GEM MAR04561Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is metabolised by ALDH1B1ProteinHuman-GEM MAR04559Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is metabolised by ALDH1B1ProteinHuman-GEM MAR00051Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is metabolised by ALDH2ProteinHuman-GEM MAR04559Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is metabolised by ALDH2ProteinHuman-GEM MAR00051Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is metabolised by ALDH3A2ProteinHuman-GEM MAR04559Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is metabolised by ALDH7A1ProteinHuman-GEM MAR04559Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is metabolised by ALDH9A1ProteinHuman-GEM MAR04559Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is metabolised by ALDH9A1ProteinRhea RHEA:31215Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is metabolised by AOX1ProteinHuman-GEM MAR04560Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is metabolised by MAOAProteinRhea RHEA:69072Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is a substrate of ADHFE1ProteinHuman-GEM MAR04561Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is a substrate of ADHFE1ProteinHuman-GEM MAR02858Inferred only
Reactions
8 reactions
(5-hydroxyindol-3-yl)acetaldehyde+water+NAD(+)(5-hydroxyindol-3-yl)acetate+2proton+NADH(2-)
Reaction pageLeft to rightBalancedEC 1.2.1.88GO:0005759
Human-GEM MAR00051CC BY 4.0Reference data
MAM01110m+NADP(3-)(5-hydroxyindol-3-yl)acetaldehyde+proton+NADPH(4-)
Catalysed by ADHFE1
Reaction pageReversibleBalancedEC 1.1.1.1GO:0005759
Human-GEM MAR02858CC BY 4.0Reference data
water+dioxygen+serotonin(5-hydroxyindol-3-yl)acetaldehyde+proton+hydrogen peroxide+ammonium
Reaction pageLeft to rightBalancedEC 1.4.3.4GO:0005829
Human-GEM MAR04558CC BY 4.0Reference data
(5-hydroxyindol-3-yl)acetaldehyde+water+NAD(+)(5-hydroxyindol-3-yl)acetate+2proton+NADH(2-)
Catalysed by ALDH3A2 or ALDH2 or ALDH1B1 or ALDH9A1 or ALDH7A1
Reaction pageLeft to rightBalancedEC 1.2.1.3GO:0005829
Human-GEM MAR04559CC BY 4.0Reference data
(5-hydroxyindol-3-yl)acetaldehyde+water+dioxygen(5-hydroxyindol-3-yl)acetate+proton+hydrogen peroxide
Catalysed by AOX1
Reaction pageLeft to rightBalancedEC 1.2.3.1GO:0005829
Human-GEM MAR04560CC BY 4.0Reference data
(5-hydroxyindol-3-yl)acetaldehyde+proton+NADPH(4-)MAM01110c+NADP(3-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1GO:0005829
Human-GEM MAR04561CC BY 4.0Reference data
(5-hydroxyindol-3-yl)acetaldehyde+NAD(1-)+water(5-hydroxyindol-3-yl)acetate+NADH(2-)+2hydron
Catalysed by ALDH9A1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:31215CC BY 4.0Reference data
serotonin+dioxygen+water(5-hydroxyindol-3-yl)acetaldehyde+hydrogen peroxide+ammonium
Catalysed by MAOA
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:69072CC BY 4.0Reference data
Other names
4 names
Resolves to: (5-hydroxyindol-3-yl)acetaldehyde
- Also called
- 5-Hial5-Hydroxyindole-3-acetaldehyde5-Hydroxyindoleacetaldehyde
- Systematic name
- (5-hydroxy-1H-indol-3-yl)acetaldehyde