3-hydroxy-L-kynurenine

1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

Catalysed by KYNU

1. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O

Catalysed by KYAT3, AADAT

1. L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O

Catalysed by KMO

1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

Catalysed by KYNU

1. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O

Catalysed by KYAT3, AADAT

1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

Catalysed by KYNUmitochondrial matrixOne of 29 routes

1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

Catalysed by KYNU, AGXT2One of 2 routes