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Proteins/UNIPROT:Q9Y694
[Isoform 2]: Functions as a Na(+)-independent bidirectional multispecific transporter. Contributes to the renal and hepatic elimination of endogenous organic compounds from the systemic circulation into the urine and bile, respectively. Capable of transporting a wide range of purine and pyrimidine nucleobases, nucleosides and nucleotides, with cGMP, 2'deoxyguanosine and GMP being the preferred substrates. Functions as a pH- and chloride-independent cGMP bidirectional facilitative transporter that can regulate both intracellular and extracellular levels of cGMP and may be involved in cGMP signaling pathways. Mediates orotate/glutamate bidirectional exchange and most likely display a physiological role in hepatic release of glutamate into the blood. Involved in renal secretion and possible reabsorption of creatinine. Able to uptake prostaglandin E2 (PGE2) and may contribute to PGE2 renal excretion (Probable). Also transports alpha-ketoglutarate and urate. Apart from the orotate/glutamate exchange, the counterions for the uptake of other SLC22A7/OAT2 substrates remain to be identified..
[Isoform 1]: Non functional transporter..
[Isoform 3]: Involved in the uptake of prostaglandin F2-alpha (PGF2-alpha)..
Function from UniProtKB (Q9Y694), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
29 statements
29 statements · 4 reference databases · Subject: SLC22A7 · Sources: Bgee, Human-GEM, Rhea, WikiPathways
22 reactions
L-glutamate(1-)+orotic acidL-glutamate(1-)+orotic acid
Transported by SLC22A7
Reaction pageReversibleBalancedEC 3.1.1.31cytosol, extracellular space
Human-GEM MAR09031CC BY 4.0Reference data
2-oxoglutarate(2-)+MAM01571e2-oxoglutarate(2-)+MAM01571c
5 names
Resolves to: SLC22A7
Human-GEM MAR09588CC BY 4.0Reference data
2-oxoglutarate(2-)+dehydroepiandrosterone 3-sulfate2-oxoglutarate(2-)+dehydroepiandrosterone 3-sulfate
Transported by SLC22A7 or SLC22A11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR09623CC BY 4.0Reference data
2-oxoglutarate(2-)+estrone 3-sulfate2-oxoglutarate(2-)+estrone 3-sulfate
Transported by SLC22A7 or SLC22A11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR09624CC BY 4.0Reference data
folic acid+sulfatefolic acid+sulfate
Transported by SLC22A7 or SLC22A8
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR09884CC BY 4.0Reference data
MAM03418eMAM03418c
Transported by SLC22A7
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR12473CC BY 4.0Reference data
MAM03801eMAM03801c
Transported by SLC22A7
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR12806CC BY 4.0Reference data
prostaglandin E2prostaglandin E2
Transported by SLC22A2 or SLC22A1 or SLCO2B1 or SLCO1A2 or SLC51A or SLC51B or SLCO2A1 or SLCO4A1 or SLCO1B3 or SLC22A11 or SLCO3A1 or SLC22A7 and 1 more alternative
Reaction pageLeft to rightBalanced
Rhea RHEA:50984CC BY 4.0Reference data
prostaglandin F2alphaprostaglandin F2alpha
Transported by SLC22A2 or SLC22A1 or SLC22A11 or SLCO3A1 or SLC22A7
Reaction pageLeft to rightBalanced
Rhea RHEA:50988CC BY 4.0Reference data
Transported by SLC2A2 or SLC29A2 or SLC17A1 or SLC29A3 or SLC2A9 or SLC22A7
Reaction pageReversibleBalanced
Rhea RHEA:60368CC BY 4.0Reference data
estrone 3-sulfateestrone 3-sulfate
Transported by SLCO2B1 or SLCO1A2 or SLCO4C1 or SLC51A or SLC51B or SLCO4A1 or SLCO1B3 or SLCO1C1 or SLCO3A1 or SLC22A7 or SLCO1B1
Reaction pageLeft to rightBalanced
Rhea RHEA:71835CC BY 4.0Reference data
orotate+L-glutamate(1-)orotate+L-glutamate(1-)
Transported by SLC22A7
Reaction pageDirection not assertedBalanced
Rhea RHEA:72043CC BY 4.0Reference data