3-sulfinopyruvate

Three steps

• 13-cis-retinalReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. retinal dehydrogenase (13-cis-retinal)

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 4 morecytosol, extracellular space, endoplasmic reticulum

• tert-butanolReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by TSTD1, CLIC2, GPX1, GPX2 and 2 morecytosol

• L-ornithineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and ornithine (cytosol to extracellular)

  Catalysed by AGXT2, SLC7A6cytosol, mitochondrial matrix, extracellular spaceOne of 7 routes

• N-(acetyl)-sphing-4-enineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 2 morecytosol, extracellular space

• gamma-Glu-AlaReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by AGXT2, GGT1, GGT5, GGTLC2 and 3 morecytosol, mitochondrial matrix, extracellular space

• taurineReach from here →
  1. 3-sulfino-L-alanine + 2-oxoglutarate = 3-sulfinopyruvate + L-glutamate
  2. 3-sulfino-L-alanine carboxy-lyase
  3. Hypotaurine Oxidase, Extracellular

  Catalysed by GOT1, GAD1, CSADcytosol, extracellular spaceOne of 4 routes

• acetoacetyl-CoAReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate

  Catalysed by AACScytosol, mitochondrial matrixOne of 2 routes

• glycineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-Alanine:glyoxylate aminotransferase

  Catalysed by AGXT2, AGXTcytosol, mitochondrial matrixOne of 14 routes

• (S)-malyl-CoAReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate

  Catalysed by ME2, SUCLG1, SUCLA2cytosol

• (R)-methylmalonyl-CoAReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by AGXT2, ALDH6A1cytosol, mitochondrial matrix

• butanoyl-CoAReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. transport of butyrate and pyruvate (cytosol to extracellular)
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 8 morecytosol, extracellular spaceOne of 2 routes

• propanoyl-CoAReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
  3. 2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+)

  Catalysed by AGXT2, ALDH6A1cytosol

• prostaglandin E1Reach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. prostaglandin E1(out) + 2 (S)-lactate(in) = prostaglandin E1(in) + 2 (S)-lactate(out)

  Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin F2alphaReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. prostaglandin F2alpha(out) + 2 (S)-lactate(in) = prostaglandin F2alpha(in) + 2 (S)-lactate(out)

  Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin H2Reach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)

  Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin D2Reach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. prostaglandin D2(out) + 2 (S)-lactate(in) = prostaglandin D2(in) + 2 (S)-lactate(out)

  Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by TSTD1, GPX1, GPX2, GPX4cytosol

• D-alanineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by AGXT2, SLC7A10cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• (13S)-hydroperoxy-(9Z,11E)-octadecadienoateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. sulfite:ferricytochrome-c oxidoreductase
  3. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion

  Catalysed by SUOXcytosol, mitochondrial matrix

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by SLC25A10, ASLcytosol, mitochondrial matrixOne of 4 routes

• (R)-S-lactoylglutathioneReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (R)-S-lactoylglutathione = methylglyoxal + glutathione

  Catalysed by TSTD1, GLO1cytosol

• N-acetyl-D-glucosamine 6-phosphateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 2 morecytosol, extracellular space

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

  Catalysed by SLC25A10, ADSL, TNRC6Bcytosol, mitochondrial matrixOne of 4 routes

• S-formylglutathioneReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. S-formylglutathione + H2O = formate + glutathione + H(+)

  Catalysed by TSTD1, ESDcytosol

• D-threonineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

  Catalysed by AGXT2, SLC7A10cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• CMP-N-acetyl-beta-neuraminateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. CTP:N-acetylneuraminate cytidylyltransferase

  Catalysed by NPL, CMAScytosol, nucleusOne of 2 routes

• N-sulfo-D-glucosamineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. sulfite:ferricytochrome-c oxidoreductase
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by SUOX, SGSHcytosol, mitochondrial matrix

• dehydroepiandrosterone 3-sulfateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. sulfite:ferricytochrome-c oxidoreductase
  3. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)

  Catalysed by SUOX, STScytosol, mitochondrial matrix

• L-tryptophanReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and tryptophan (cytosol to extracellular)

  Catalysed by AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 10 routes

• L-threonineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

  Catalysed by AGXT2, SLC7A10cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 5 routes

• L-kynurenineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by AGXT2, KYNUcytosol, mitochondrial matrix

• beta-alanineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

  Catalysed by AGXT2, SLC7A10cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 4 routes

• leukotriene C4Reach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. leukotriene C4 = leukotriene A4 + glutathione

  Catalysed by TSTD1, MGST3, GSTM4, LTC4S and 1 morecytosol

• 2-hydroxy-3-oxopropanoateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. L-Serine:pyruvate aminotransferase
  3. hydroxypyruvate aldose-ketose-isomerase

  Catalysed by AGXT, HYIcytosolOne of 2 routes

• L-asparagineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and asparagine (cytosol to extracellular)

  Catalysed by AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 11 routes

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. 3-sulfino-L-alanine + 2-oxoglutarate = 3-sulfinopyruvate + L-glutamate
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by GOT1, SLC25A12, SLC25A13, AGAmitochondrial matrix, cytosol

• L-phenylalanineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and phenylalanine (cytosol to extracellular)

  Catalysed by AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 14 routes

• 3-hydroxy-L-kynurenineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by AGXT2, KYNUcytosol, mitochondrial matrix

• L-homocysteineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by TYW1B, TYW1, BHMT2cytosol

• adenosine 5'-phosphosulfateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. sulfite:ferricytochrome-c oxidoreductase
  3. ATP:sulfate adenylyltransferase

  Catalysed by SUOX, PAPSS1, PAPSS2cytosol, mitochondrial matrixOne of 4 routes

• S-methyl-L-methionineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by TYW1B, TYW1, BHMT2cytosol

• N-acetylputrescineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 2 morecytosol, extracellular space

• (2R)-2-phosphoglycerateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. pyruvate kinase (dTDP)
  3. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)

  Catalysed by PKM, PKLR, ENO1, ENO2 and 1 morecytosol

• glutathione disulfideReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by MPST, TST, TSTD1cytosolOne of 23 routes

• L-tyrosineReach from here →
  1. 3-sulfino-L-alanine + 2-oxoglutarate = 3-sulfinopyruvate + L-glutamate
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)

  Catalysed by GOT1, SLC25A12, SLC25A13, SLC7A13mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by AGXT2cytosol, mitochondrial matrixOne of 8 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by AGXT2, SLC1A4cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-oxo-L-prolineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. glutathione = L-cysteinylglycine + 5-oxo-L-proline

  Catalysed by TSTD1, CHAC2, CHAC1cytosol

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by SLC25A10, ADSLcytosol, mitochondrial matrixOne of 4 routes

• kynurenateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O

  Catalysed by MPST, AADATcytosolOne of 2 routes