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Proteins/UNIPROT:P09104
Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis (By similarity). Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity)..
Function from UniProtKB (P09104), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
159 statements
159 statements · 8 reference databases · Subject: ENO2 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
2 reactions
(2R)-2-phosphoglyceratewater+phosphoenolpyruvic acid
Catalysed by ENO1 or ENO3 or ENO2
Reaction pageReversibleBalancedEC 4.2.1.11cytosol
Human-GEM MAR04363CC BY 4.0Reference data
5 names
Resolves to: ENO2
Reaction pageReversibleBalanced
Rhea RHEA:10164CC BY 4.0Reference data