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Proteins/UNIPROT:Q16762
Catalyzes the transfer of sulfur ion from thiosulfate to cyanide, although other thiol compounds, besides cyanide, can act as sulfur ion acceptors (By similarity). It also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Has a pivotal role in cyanide detoxification. Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA..
Function from UniProtKB (Q16762), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
145 statements
145 statements · 7 reference databases · Subject: TST · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
5 reactions
proton+2-oxo-3-sulfanylpropanoate+sulfitethiosulfate+pyruvate
Reaction pageLeft to rightBalancedEC 2.8.1.2cytosol
Human-GEM MAR03928CC BY 4.0Reference data
2-oxo-3-sulfanylpropanoate+sulfitepyruvate+thiosulfate
Catalysed by MPST or
1 name
Resolves to: TST
Reaction pageLeft to rightBalancedEC 2.8.1.2cytosol
Human-GEM MAR06515CC BY 4.0Reference data
hydrogen cyanide+2-oxo-3-sulfanylpropanoateproton+pyruvate+thiocyanate
Reaction pageLeft to rightBalancedEC 2.8.1.2cytosol
Human-GEM MAR06518CC BY 4.0Reference data
hydrogen cyanide+thiosulfateproton+sulfite+thiocyanate
Reaction pageReversibleBalancedEC 2.8.1.1mitochondrial matrix
Human-GEM MAR06520CC BY 4.0Reference data
thiosulfate+hydrogen cyanidethiocyanate+sulfite+2hydron
Catalysed by TST
Reaction pageDirection not assertedBalanced
Rhea RHEA:16881CC BY 4.0Reference data