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Proteins/UNIPROT:Q92536
Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis. Also exchanges L-arginine with L-lysine in a sodium-independent manner. The transport mechanism is electroneutral and operates with a stoichiometry of 1:1. Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells. May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity)..
Function from UniProtKB (Q92536), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 9 · transported by
9 compounds
9 compounds.
0 reported routes9 assembled routes
712 statements
712 statements · 6 reference databases · Subject: SLC7A6 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
263 reactions
L-arginine+CHEBI:18019L-arginine+CHEBI:18019
Transported by SLC7A6 or SLC7A5 or SLC3A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05578CC BY 4.0Reference data
6 names
Resolves to: SLC7A6
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05579CC BY 4.0Reference data
CHEBI:15971+CHEBI:18019CHEBI:15971+CHEBI:18019
Transported by SLC7A6 or SLC7A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05580CC BY 4.0Reference data
L-citrulline+CHEBI:18019L-citrulline+CHEBI:18019
Transported by SLC7A6 or SLC7A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05581CC BY 4.0Reference data
L-arginine+L-ornithineL-arginine+L-ornithine
Transported by SLC7A6 or SLC7A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05582CC BY 4.0Reference data
L-arginine+CHEBI:15971L-arginine+CHEBI:15971
Transported by SLC7A6 or SLC7A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05583CC BY 4.0Reference data
L-arginine+L-citrullineL-arginine+L-citrulline
Transported by SLC7A6 or SLC7A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05584CC BY 4.0Reference data
CHEBI:15971+L-ornithineCHEBI:15971+L-ornithine
Transported by SLC7A6 or SLC7A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05585CC BY 4.0Reference data
L-citrulline+CHEBI:15971L-citrulline+CHEBI:15971
Transported by SLC7A6 or SLC7A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05586CC BY 4.0Reference data
L-alanine+glycine+sodium(1+)L-alanine+glycine+sodium(1+)
Transported by SLC7A6 or SLC7A5
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05587CC BY 4.0Reference data
L-glutamine+glycine+sodium(1+)L-glutamine+glycine+sodium(1+)
Transported by SLC7A6
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05588CC BY 4.0Reference data
glycine+sodium(1+)+L-seryl residueglycine+sodium(1+)+L-seryl residue
Transported by SLC7A6 or SLC7A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05589CC BY 4.0Reference data