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Proteins/UNIPROT:Q16873
Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity. Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions..
Function from UniProtKB (Q16873), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
35 statements
35 statements · 5 reference databases · Subject: LTC4S · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
5 reactions
CHEBI:16856+leukotriene A4leukotriene C4
Catalysed by LTC4S
Reaction pageLeft to rightBalancedEC 4.4.1.20cytosol
Human-GEM MAR01081CC BY 4.0Reference data
CHEBI:16856+leukotriene A5MAM02367c
Catalysed by LTC4S
Reaction pageReversibleBalancedEC 4.4.1.20cytosol
Human-GEM MAR02552CC BY 4.0Reference data
4 names
Resolves to: LTC4S
Catalysed by LTC4S
Reaction pageLeft to rightBalancedEC 4.4.1.20endoplasmic reticulum
Human-GEM MAR08550CC BY 4.0Reference data
leukotriene C4leukotriene A4+glutathione
Catalysed by MGST3 or GSTM4 or LTC4S or MGST2
Reaction pageReversibleBalanced
Rhea RHEA:17617CC BY 4.0Reference data
(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate+glutathione(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate
Reaction pageLeft to rightBalanced
Rhea RHEA:53508CC BY 4.0Reference data