L-aspartate

Three steps

• formateReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)
  3. oxalate(in) + formate(out) = oxalate(out) + formate(in)

  Catalysed by SLC25A14, SLC25A30, SLC26A2, SLC26A6 and 1 moreinner side of the membrane, outer side of the membraneOne of 3 routes

• hexadecanoic acidReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by NAT8L, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosol, endoplasmic reticulumOne of 4 routes

• nicotinic acid D-ribonucleotideReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. Transport of Quinolinic Acid
  3. Nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase (carboxylating)

  Catalysed by SLC25A14, SLC25A30, SLC22A6, QPRTinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoateReach from here →
  1. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  2. Transport of 3-Hydroxy-L-Kynurenine
  3. 3-hydroxy-L-kynurenine:2-oxoglutarate aminotransferase

  Catalysed by SLC7A13, SLC7A5, KYAT1, KYAT3 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 3-hydroxyanthranilic acidReach from here →
  1. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  2. Transport of 3-Hydroxy-L-Kynurenine
  3. 3-Hydroxy-L-kynurenine hydrolase

  Catalysed by SLC7A13, SLC7A5, KYNUinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 1-acylglycerone 3-phosphateReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:glycerone-phosphate O-acyltransferase

  Catalysed by NAT8L, ASAH1, ACER2, ACER1 and 2 moremitochondrial matrix, Golgi apparatus, cytosol

• keto-D-fructose 6-phosphateReach from here →
  1. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  2. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  3. D-glucosamine-6-phosphate aminohydrolase (ketol isomerizing)

  Catalysed by SLC7A13, GFPT2, GFPT1, GNPDA1 and 1 moreinner side of the membrane, outer side of the membrane, cytosol

• androsteroneReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. steroid sulfatase (androsterone sulfate)
  3. steroid sulfatase (androsterone sulfate)

  Catalysed by SLC25A14, SLC25A30, STSinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• phosphatidylethanolamineReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase

  Catalysed by NAT8L, ASAH1, ACER2, ACER1 and 6 moremitochondrial matrix, Golgi apparatus, cytosol

• 11-cis-retinalReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. 11-cis-retinol:NAD+ oxidoreductase

  Catalysed by NAT8L, DGAT1, LRAT, AWAT1 and 9 moremitochondrial matrix, cytosolOne of 4 routes

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by NAT8L, ASAH1, ACER2, ACER1 and 5 moremitochondrial matrix, Golgi apparatus, cytosol

• hexadecan-1-olReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Palmitate:CoA ligase (AMP-forming)
  3. formate dehydrogenase (palmitoyl-CoA)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosol, peroxisome

• homogentisateReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  3. 4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)

  Catalysed by SLC7A13, TAT, HPDinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• CHEBI:16174Reach from here →
  1. L-Aspartate:tRNA(Asp) ligase (AMP-forming)
  2. glycyl-tRNA(gly) phosphorylation
  3. 2'-deoxyadenosine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase

  Catalysed by DARS1, TXN, RRM1, RRM2 and 2 morecytosol

• ureaReach from here →
  1. L-Citrulline:L-aspartate ligase (AMP-forming)
  2. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)
  3. L-Arginine amidinohydrolase

  Catalysed by ASS1, ASL, ARG1cytosolOne of 4 routes

• 11-cis-retinyl hexadecanoateReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Palmitate:CoA ligase (AMP-forming)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 10 moremitochondrial matrix, cytosolOne of 3 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. Oxaloacetate Decarboxylase
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by GOT2, FAHD1, AGXT2mitochondrial matrix, cytosolOne of 3 routes

• CHEBI:16284Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. GTP:oxaloacetate carboxy-lyase (adding GTP
  3. dATP:pyruvate 2-O-phosphotransferase

  Catalysed by GOT2, PCK1, PKM, PKLRmitochondrial matrix, cytosolOne of 2 routes

• cob(II)alaminReach from here →
  1. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2

  Catalysed by SLC7A13, CDKAL1, MTRRinner side of the membrane, outer side of the membrane

• 17beta-hydroxy-5alpha-androstan-3-oneReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. steroid sulfatase (5-alpha-dihydrotestosterone)
  3. steroid sulfatase (5-alpha-dihydrotestosterone)

  Catalysed by SLC25A14, SLC25A30, STSinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• phosphatidic acidReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by NAT8L, ASAH1, ACER2, ACER1 and 10 moremitochondrial matrix, Golgi apparatusOne of 7 routes

• iodideReach from here →
  1. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  2. transport of asparagine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by ASNS, SLC7A5, TPOcytosol, extracellular spaceOne of 25 routes

• cis-aconitateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. cis-aconitate(in) + citrate(out) = cis-aconitate(out) + citrate(in)

  Catalysed by GOT2, CS, SLC25A1mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• ubiquinonesReach from here →
  1. L-Citrulline:L-aspartate ligase (AMP-forming)
  2. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)
  3. succinate:quinone oxidoreductase

  Catalysed by ASS1, ASL, SDHD, SDHB and 2 morecytosol, mitochondrial matrix

• 2-phenylacetaldehydeReach from here →
  1. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  2. L-phenylalanine carboxy-lyase (phenylethylamine-forming)
  3. Phenethylamine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC7A13, DDC, AOC2, AOC1 and 3 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• nitric oxideReach from here →
  1. L-Citrulline:L-aspartate ligase (AMP-forming)
  2. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by ASS1, ASL, NOS3, NOS1 and 1 morecytosolOne of 3 routes

• CHEBI:16497Reach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. GTP:oxaloacetate carboxy-lyase (adding GTP
  3. dGTP:pyruvate 2-O-phosphotransferase

  Catalysed by GOT2, PCK1, PKM, PKLRmitochondrial matrix, cytosolOne of 2 routes

• selaneReach from here →
  1. oxaloacetate + L-alanine = L-aspartate + pyruvate
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by AGXT2, SCLYcytosolOne of 3 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  2. transport of asparagine and ornithine (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by ASNS, SLC7A6, ACY1cytosol, extracellular spaceOne of 2 routes

• anthranilateReach from here →
  1. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  2. Transport of L-Kynurenine
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by SLC7A13, SLC43A1, KYNUinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• D-alanyl-D-alanineReach from here →
  1. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  2. transport of D-alanine and glutamine (cytosol to extracellular)
  3. Formation of Alanylalanine

  Catalysed by SLC7A13, SLC3A2, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• pregnenoloneReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. Steryl-Sulfatase
  3. Pregnenolone-sulfate sulfohydrolase

  Catalysed by SLC25A14, SLC25A30, STSinner side of the membrane, outer side of the membrane, Golgi apparatus, cytosolOne of 4 routes

• (S)-lactateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. Oxaloacetate Decarboxylase
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by GOT2, FAHD1, LDHA, LDHB and 3 moremitochondrial matrix, cytosolOne of 2 routes

• 3'-deoxy-3',4'-didehydro-CTPReach from here →
  1. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

  Catalysed by SLC7A13, CDKAL1, RSAD2inner side of the membrane, outer side of the membrane

• pyridoxineReach from here →
  1. oxaloacetate + L-alanine = L-aspartate + pyruvate
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. pyridoxine-5'-phosphate phosphohydrolase

  Catalysed by AGXT2, SCLY, PHOSPHO2, PDXPcytosolOne of 2 routes

• orotic acidReach from here →
  1. carbamoyl-phosphate:L-aspartate carbamoyltransferase
  2. (S)-dihydroorotate amidohydrolase
  3. (S)-dihydroorotate:NAD+ oxidoreductase

  Catalysed by CAD, DHODHcytosol

• 2-oxobutanoateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. Oxaloacetate Decarboxylase
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by GOT2, FAHD1, AGXT2mitochondrial matrix, cytosolOne of 10 routes

• (S)-2-hydroxyglutarateReach from here →
  1. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2

  Catalysed by SLC7A13, CDKAL1, L2HGDHinner side of the membrane, outer side of the membrane

• enol-phenylpyruvateReach from here →
  1. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  2. Phenylalanine Transaminase, Mitochondrial
  3. 3-phenylpyruvate = enol-phenylpyruvate

  Catalysed by SLC7A13, GOT2, TAT, MIFinner side of the membrane, outer side of the membrane, mitochondrial matrix

• 3-fumarylpyruvateReach from here →
  1. L-Citrulline:L-aspartate ligase (AMP-forming)
  2. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by ASS1, ASL, FAHD1cytosolOne of 2 routes

• CHEBI:16856Reach from here →
  1. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  2. transport of asparagine and glycine (cytosol to extracellular)
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by ASNS, GSScytosol, extracellular spaceOne of 14 routes

• pantetheine 4'-phosphateReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acid phosphatase 2, lysosomal (CoA)
  3. Dephospho-CoA nucleotidohydrolase

  Catalysed by NAT8L, ACP2, ENPP3, ENPP1mitochondrial matrix, lysosome, cytosolOne of 2 routes

• psychosineReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. UDP-alpha-D-galactose:sphingosine 1-beta-galactosyltransferase

  Catalysed by NAT8L, ASAH1, ACER2, ACER1 and 1 moremitochondrial matrix, Golgi apparatus, cytosol

• glyoxylic acidReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. D-aspartate:2-oxoglutarate aminotransferase
  3. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)

  Catalysed by GOT2, HOGA1mitochondrial matrixOne of 2 routes

• trans-1,2-dithiane-4,5-diolReach from here →
  1. oxaloacetate + L-alanine = L-aspartate + pyruvate
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. selenocysteine lyase (dithiothreitol)

  Catalysed by AGXT2, SCLYcytosol

• ferrocytochrome cReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by SLC25A14, SLC25A30, SUOXinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• 1-acyl-sn-glycerol 3-phosphateReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase

  Catalysed by NAT8L, ASAH1, ACER2, ACER1 and 5 moremitochondrial matrix, Golgi apparatus

• a cholesterol esterReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. an acyl-CoA + cholesterol = a cholesterol ester + CoA

  Catalysed by NAT8L, ASAH1, ACER2, ACER1 and 3 moremitochondrial matrix, Golgi apparatus

• (R)-3-hydroxybutyric acidReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. Oxaloacetate Decarboxylase
  3. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

  Catalysed by GOT2, FAHD1, SLC16A4, SLC16A5 and 4 moremitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• taurolithocholateReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. bile acid-CoA:amino acid N-acyltransferase (lithocholate)

  Catalysed by NAT8L, BAATmitochondrial matrix, cytosolOne of 2 routes