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Proteins/UNIPROT:P23921
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Function from UniProtKB (P23921), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
259 statements
259 statements · 6 reference databases · Subject: RRM1 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
15 reactions
CHEBI:16174+water+thioredoxin disulfideADP+thioredoxin dithiol
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1mitochondrial matrix
Human-GEM MAR02352CC BY 4.0Reference data
3 names
Resolves to: RRM1
Reaction pageLeft to rightBalancedEC 1.17.4.1mitochondrial matrix
Human-GEM MAR02357CC BY 4.0Reference data
ATP+thioredoxin dithiolCHEBI:16284+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol
Human-GEM MAR04611CC BY 4.0Reference data
ADP+thioredoxin dithiolCHEBI:16174+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol
Human-GEM MAR04612CC BY 4.0Reference data
GTP+thioredoxin dithiolCHEBI:16497+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol
Human-GEM MAR04614CC BY 4.0Reference data
GDP+thioredoxin dithiolCHEBI:28862+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol
Human-GEM MAR04615CC BY 4.0Reference data
CHEBI:17677+thioredoxin dithioldCTP+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol
Human-GEM MAR04617CC BY 4.0Reference data
thioredoxin dithiol+UTPdUTP+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol
Human-GEM MAR04618CC BY 4.0Reference data
CHEBI:17239+thioredoxin dithioldCDP+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol
Human-GEM MAR04619CC BY 4.0Reference data
thioredoxin dithiol+UDPMAM01754c+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol
Human-GEM MAR04621CC BY 4.0Reference data
CHEBI:16174+water+thioredoxin disulfideADP+thioredoxin dithiol
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1mitochondrial matrix
Human-GEM MAR05415CC BY 4.0Reference data
CHEBI:28862+water+thioredoxin disulfideGDP+thioredoxin dithiol
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1mitochondrial matrix
Human-GEM MAR05416CC BY 4.0Reference data