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Proteins/UNIPROT:P10599
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity..
ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
Function from UniProtKB (P10599), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
146 statements
146 statements · 5 reference databases · Subject: TXN · Sources: gene ontology, Hetionet, Human-GEM, Reactome, WikiPathways
14 reactions
CHEBI:16174+water+thioredoxin disulfideADP+thioredoxin dithiol
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1mitochondrial matrix
Human-GEM MAR02352CC BY 4.0Reference data
8 names
Resolves to: TXN
Reaction pageLeft to rightBalancedEC 1.17.4.1mitochondrial matrix
Human-GEM MAR02357CC BY 4.0Reference data
ATP+thioredoxin dithiolCHEBI:16284+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol
Human-GEM MAR04611CC BY 4.0Reference data
ADP+thioredoxin dithiolCHEBI:16174+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol
Human-GEM MAR04612CC BY 4.0Reference data
GTP+thioredoxin dithiolCHEBI:16497+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol
Human-GEM MAR04614CC BY 4.0Reference data
GDP+thioredoxin dithiolCHEBI:28862+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol
Human-GEM MAR04615CC BY 4.0Reference data
CHEBI:17677+thioredoxin dithioldCTP+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol
Human-GEM MAR04617CC BY 4.0Reference data
thioredoxin dithiol+UTPdUTP+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol
Human-GEM MAR04618CC BY 4.0Reference data
CHEBI:17239+thioredoxin dithioldCDP+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol
Human-GEM MAR04619CC BY 4.0Reference data
thioredoxin dithiol+UDPMAM01754c+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol
Human-GEM MAR04621CC BY 4.0Reference data
CHEBI:16174+water+thioredoxin disulfideADP+thioredoxin dithiol
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1mitochondrial matrix
Human-GEM MAR05415CC BY 4.0Reference data
CHEBI:28862+water+thioredoxin disulfideGDP+thioredoxin dithiol
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1mitochondrial matrix
Human-GEM MAR05416CC BY 4.0Reference data